{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:32:30Z","timestamp":1792265550695,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["108\u20102321\u2010B\u2010001\u2010028\u2010MY2"],"award-info":[{"award-number":["108\u20102321\u2010B\u2010001\u2010028\u2010MY2"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110\u20102314\u2010B\u2010002\u2010060\u2010MY3"],"award-info":[{"award-number":["110\u20102314\u2010B\u2010002\u2010060\u2010MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["111\u20102321\u2010B\u2010001\u2010009"],"award-info":[{"award-number":["111\u20102321\u2010B\u2010001\u2010009"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\u20102321\u2010B\u2010001\u2010009"],"award-info":[{"award-number":["112\u20102321\u2010B\u2010001\u2010009"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The pathophysiology of sarcopenia is complex and multifactorial and has not been fully elucidated. The impact of resistance training and nutritional support (RTNS) on metabolomics and lipodomics in older adults with sarcopenia remains uncertain. This study aimed to explore potential biomarkers of sarcopenia and clinical indicators of RTNS in older sarcopenic adults.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Older individuals diagnosed with sarcopenia through routine health checkups at a community hospital were recruited for a 12\u2010week randomized controlled trial focusing on RTNS. Plasma metabolomic and lipidomic profiles of 45 patients with sarcopenia and 47 matched controls were analysed using\n 1<\/jats:sup>\n H\u2010nuclear magnetic resonance (\n 1<\/jats:sup>\n H\u2010NMR) and liquid chromatography\u2010mass spectrometer (LC\u2013MS).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At baseline, the patient and control groups had similar age, sex, and height distribution. The patient group had significantly lower weight, BMI, grip strength, gait speed, skeletal muscle index, lean mass of both the upper and lower limbs, and lower limb bone mass. There was a significant difference in 12 metabolites between the control and patient groups. They are isoleucine (patient\/control fold change [FC]\u00a0=\u00a00.86\u00a0\u00b1\u00a00.04,\n P<\/jats:italic>\n \u00a0=\u00a00.0005), carnitine (FC\u00a0=\u00a01.05\u00a0\u00b1\u00a00.01,\n P<\/jats:italic>\n \u00a0=\u00a00.0110), 1\u2010methylhistamine\/3\u2010methylhistamine (FC\u00a0=\u00a01.24\u00a0\u00b1\u00a00.14,\n P<\/jats:italic>\n \u00a0=\u00a00.0039), creatinine (FC\u00a0=\u00a00.71\u00a0\u00b1\u00a00.04,\n P<\/jats:italic>\n \u00a0<\u00a00.0001), carnosine (FC\u00a0=\u00a00.71\u00a0\u00b1\u00a00.04,\n P<\/jats:italic>\n \u00a0=\u00a00.0007), ureidopropionic acid (FC\u00a0=\u00a00.61\u00a0\u00b1\u00a00.10,\n P<\/jats:italic>\n \u00a0=\u00a00.0107), uric acid (FC\u00a0=\u00a00.88\u00a0\u00b1\u00a00.03,\n P<\/jats:italic>\n \u00a0=\u00a00.0083), PC (18:2\/20:0) (FC\u00a0=\u00a00.69\u00a0\u00b1\u00a00.03,\n P<\/jats:italic>\n \u00a0=\u00a00.0010), PC (20:2\/18:0) (FC\u00a0=\u00a00.70\u00a0\u00b1\u00a00.06,\n P<\/jats:italic>\n \u00a0=\u00a00.0014), PC (18:1\/20:1) (FC\u00a0=\u00a00.74\u00a0\u00b1\u00a00.05,\n P<\/jats:italic>\n \u00a0=\u00a00.0015), PI 32:1 (FC\u00a0=\u00a04.72\u00a0\u00b1\u00a00.17,\n P<\/jats:italic>\n \u00a0=\u00a00.0006), and PI 34:3 (FC\u00a0=\u00a01.88\u00a0\u00b1\u00a00.13,\n P<\/jats:italic>\n \u00a0=\u00a00.0003). Among them, carnitine, 1\u2010methylhistamine\/3\u2010methylhistamine, creatinine, ureidopropionic acid, uric acid, PI 32:1, and PI 34:3 were first identified. Notably, PI 32:1 had highest diagnostic accuracy (0.938) for sarcopenia. 1\u2010Methylhistamine\/3\u2010methylhistamine, carnosine, PC (18:2\/20:0), PI 32:1, and PI 34:3 levels were not different from the control group after RTNS. These metabolites are involved in amino acid metabolism, lipid metabolism, and the PI3K\u2010AKT\/mTOR signalling pathway through the ingenuity pathway analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These findings provide information on metabolic changes, lipid perturbations, and the role of RTNS in patients with sarcopenia. They reveal new insights into its pathological mechanisms and potential therapies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcsm.13567","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T23:39:20Z","timestamp":1724283560000},"page":"2175-2186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Novel metabolic and lipidomic biomarkers of sarcopenia"],"prefix":"10.1002","volume":"15","author":[{"given":"Wei\u2010Hsiang","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources China Medical University Taichung Taiwan"},{"name":"Institute of Biopharmaceutical Sciences National Yang\u2010Ming\u2010Chiao\u2010Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San\u2010Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Master Program in Clinical 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