{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:47:51Z","timestamp":1790603271738,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Body composition parameters provide relevant prognostic significance in critical care cohorts and cancer populations. Published results regarding polytrauma patients are inconclusive to date. The goal of this study was to analyse the role of body composition parameters in severely injured trauma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive patients requiring emergency tracheal intubation and mechanical ventilation before initial computed tomography (CT) at a level\u20101 trauma centre over a 12\u2010year period (2008\u20132019) were reanalysed. The analysis included CT\u2010derived body composition parameters based upon whole\u2010body trauma CT as prognostic variables for 30\u2010day mortality, intensive care unit length of stay (ICU LOS) and mechanical ventilation duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four hundred seventy\u2010two patients (75% male) with a median age of 49\u00a0years, median injury severity score of 26 and 30\u2010day mortality rate of 22% (104 patients) met the inclusion criteria and were analysed. Regarding body composition parameters, 231 patients (49%) had visceral obesity, 75 patients had sarcopenia (16%) and 35 patients had sarcopenic obesity (7.4%). After adjustment for statistically significant univariable predictors age, body mass index, sarcopenic obesity, visceral obesity, American Society of Anesthesiologists classification \u22653, injury severity score and Glasgow Coma Scale\u00a0\u2264\u00a08 points, the Cox proportional hazard model identified sarcopenia as significant prognostic factor of 30\u2010day mortality (hazard ratio 2.84; 95% confidence interval 1.38\u20135.85;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004), which was confirmed in Kaplan\u2013Meier survival analysis (log\u2010rank\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006). In a subanalysis of 363 survivors, linear multivariable regression analysis revealed no significant associations of body composition parameters with ICU LOS and duration of mechanical ventilation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a multivariable analysis of mechanically ventilated trauma patients, CT\u2010defined sarcopenia was significantly associated with 30\u2010day mortality whereas no associations of body composition parameters with ICU LOS and duration of mechanical ventilation were observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13578","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:43:26Z","timestamp":1724651006000},"page":"2437-2446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Body composition parameters in initial CT imaging of mechanically ventilated trauma patients: Single\u2010centre observational study"],"prefix":"10.1002","volume":"15","author":[{"given":"Hans\u2010Jonas","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tihomir","family":"Dermendzhiev","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hetz","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Trauma and Plastic Surgery University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Osterhoff","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Trauma and Plastic Surgery University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kleber","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Trauma and Plastic Surgery University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Denecke","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Henkelmann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Werdehausen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Medical Faculty University of Magdeburg  Magdeburg Germany"},{"name":"Department of Anesthesiology and Intensive Care Medicine University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunther","family":"Hempel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-3406","authenticated-orcid":false,"given":"Manuel F.","family":"Struck","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Advanced Trauma Life Support\u00ae Student Course Manual","author":"American College of 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