{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:12:36Z","timestamp":1790781156681,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["91719343"],"award-info":[{"award-number":["91719343"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The prediction of the risk of developing complications after colorectal surgery for colorectal carcinoma remains imprecise. Body composition measurements on a computed tomography (CT) scan can potentially contribute to a better preoperative risk assessment. The aim of this systematic review is to evaluate the evidence for the use of body composition measurements on CT scans to predict short\u2010term complications after colorectal cancer surgery. A literature search (in PubMed, Embase and Web of Science) was performed up to 1 August 2022. Two researchers independently screened the articles, extracted data and assessed the quality of the studies using the Quality in Prognosis Studies tool. The primary outcome measure was the occurrence of complications within 30\u00a0days after surgery. Meta\u2010analysis was conducted using a random\u2010effects model to synthesize a pooled odds ratio (OR). The study protocol was registered in PROSPERO (CRD42021281010). Forty\u2010five articles with a total of 16\u00a0537 patients were included. In total, 26 body composition measures were investigated: 8 muscle\u2010related measures, 11 adipose tissue measures, 4 combined muscle and adipose tissue measures, and 3 other measures. These were investigated as potential predictors for more than 50 differently defined postoperative complications. Meta\u2010analysis was only possible for two measurements and showed that higher amounts of visceral fat increase the risk of developing overall complications (OR: 2.52 [1.58\u20134.00],\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001) and anastomotic leakage (OR: 1.76 [1.17\u20132.65],\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.006). A wide variety of body composition measurements on preoperative CT scans have been investigated as a predictive factor for postoperative complications. Visceral fat appeared to be associated with overall complications and anastomotic leakage; however, the association is weak, and its clinical relevance or applicability is questionable. The current evidence is limited by methodological heterogeneity and the risk of bias. To improve comparability of results across studies and improve decision\u2010making, future studies should use standardized methods for measuring body composition on CT scans, outcome definitions and statistical analyses.\n                  <\/jats:p>","DOI":"10.1002\/jcsm.13580","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T02:39:02Z","timestamp":1728268742000},"page":"2234-2269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association of computed tomography\u2010derived body composition and complications after colorectal cancer surgery: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-0214","authenticated-orcid":false,"given":"Claire P.M.","family":"van Helsdingen","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, 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Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariska M.G.","family":"Leeflang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Amsterdam UMC, location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hemke","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam UMC, location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep P.M.","family":"Derikx","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Gastroenterology 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