{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:40:31Z","timestamp":1792194031192,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The risk of sarcopenia in older adults with chronic kidney disease (CKD) not yet on dialysis is controversial. The aims of this study were to investigate the association among sarcopenia, diabetes and predialysis CKD and evaluate the impact of gender and ageing on the risk of sarcopenia statuses in older patients with predialysis CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The participants aged\n                      <jats:bold>\u2265<\/jats:bold>\n                      60\u2009years old were recruited from the community of New Taipei City, Taiwan. Handgrip strength, appendicular skeletal muscle mass and the 6\u2010m walk were measured. The diagnosis of sarcopenia was established based on the consensus of Asian Sarcopenia Working Group 2019. These older adults were categorised into G1, G2 and G3\u20135 according to the guidelines of Kidney Disease Improving Global Outcomes (KDIGO) after calculating the estimated glomerular filtration rate by the Modification of Diet in Renal Disease equation. The Chi\u2010square test and ANOVA were used to estimate the difference of categorical and continuous variables, respectively. Polytomous logistic regression was employed to assess the odds ratio (OR) and 95% confidence intervals (CIs) of the sarcopenia status and sarcopenia\u2010associated risk factors in the predialysis CKD patients. All tests were two\u2010sided, and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 was defined as statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 3648 older adults (mean age: 71.9\u2009\u00b1\u20096.07\u2009years), including 1701 males and 1947 females, 870 (23.9%), 94 (2.58%) and 48 (1.32%) had possible sarcopenia, sarcopenia and severe sarcopenia, respectively. After adjustment, the risk for possible sarcopenia, sarcopenia and severe sarcopenia significantly increased with ageing (OR\u2009=\u20091.11, 1.10 and 1.23; 95% CI\u2009=\u20091.10\u20131.13, 1.07\u20131.15 and 1.18\u20131.30, respectively) and male gender (OR\u2009=\u20092.26, 20.3 and 25.4; 95% CI\u2009=\u20091.87\u20132.73, 11.5\u201336.0 and 11.3\u201357.2, respectively). Compared with KDIGO G1, no significant association between KDIGO G3\u20135 and the statuses of sarcopenia was observed (OR\u2009=\u20090.97, 0.88 and 0.91; 95% CI\u2009=\u20090.75\u20131.26, 0.43\u20131.78 and 0.37\u20132.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.821, 0.718, 0.838, for possible sarcopenia, sarcopenia and severe sarcopenia, respectively). Ageing and male gender indicated a significant risk for higher sarcopenia status in older patients with predialysis CKD (0.027\u2010fold\/year and 0.284\u2010fold, respectively) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study illuminated the importance of the male sex and the ageing process on the risk of sarcopenia progression in patients with predialysis CKD. Early clinical screening and aggressive treatment for the prevention of higher sarcopenia status in advanced older male adults with predialysis CKD are recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13612","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T07:38:39Z","timestamp":1727768319000},"page":"2684-2692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on Dialysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2569-999X","authenticated-orcid":false,"given":"Yi\u2010Fang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of General Dentistry Chang Gung Memorial Hospital  Linkou Taiwan"},{"name":"Graduate Institute of Dental and Craniofacial Science, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"School of Dentistry, College of Oral Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Translational Medicine Research Center China Medical University Hospital  Taichung Taiwan"},{"name":"Program for Aging, College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Hsin","family":"Muo","sequence":"additional","affiliation":[{"name":"Management Office for Health Data China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yi","family":"Lai","sequence":"additional","affiliation":[{"name":"Internal Audit Department Far Eastern Memorial Hospital  New Taipei Taiwan"},{"name":"Graduate Institute of Medicine Yuan Ze University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-1407","authenticated-orcid":false,"given":"Chung\u2010Ta","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Oral Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Medicine Yuan Ze University  Taoyuan Taiwan"},{"name":"Department of Emergency Medicine Far Eastern Memorial Hospital  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-014-0281-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.10.036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00742-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14194077"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2023.112107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-020-00840-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101827"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121951"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.110815"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203539"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28047"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001448"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0097"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.11.025"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-11-201306040-00007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_8_20_1","first-page":"S83","article-title":"6. 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