{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:31:45Z","timestamp":1791167505962,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nutritional status, systemic inflammatory responses and muscle mass are associated with the prognosis of patients with amyotrophic lateral sclerosis (ALS). However, the optimal biomarker for predicting prognosis remains unclear. This study aimed to identify the optimal indicators of survival among the nutrition\u2010based, inflammation\u2010based and muscle mass\u2013related markers for ALS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled ALS patients from January 2014 to December 2019. Experienced neurologists followed up with the participants until January 2022. This study included a total of 17 nutritional, systemic inflammatory or muscle mass\u2013related indicators. Maximally selected rank statistics determined the cut\u2010off points for these indicators. Kaplan\u2013Meier estimation was used to assess survival. Uni\u2010 and multivariate Cox proportional hazards models were used to determine the effects of indicators on survival. Finally, time\u2010dependent receiver operating characteristic (time\u2010ROC) curves and the C\u2010index were calculated to evaluate the predictive efficacy of different indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 506 patients with ALS were enrolled in this study, including 288 males (56.9%) and 218 females (43.1%), with a mean age of 54.2\u2009\u00b1\u200910.5\u2009years. Among these ALS patients, 334 cases (68.0%) either died or underwent tracheotomy. In univariate Cox proportional hazards regression, 11 indicators were significantly associated with ALS survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). And systemic immune inflammation (SII), platelet\u2010to\u2010lymphocyte ratio (PLR), modified geriatric nutritional risk index (mGNRI), creatinine and sarcopenia index (SI, (creatinine\/cystatin C)\u2009\u00d7\u2009100) were determined as independent predictors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in multivariate Cox proportional hazards regression. A higher SI predicted longer survival (hazard ratio, 0.59; 95% confidence interval [CI], 0.46\u20130.76;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The results of time\u2010ROC and C\u2010index analyses indicated that SI had the best predictive efficacy for ALS survival, with a C\u2010index of 0.65 (95% CI, 0.54\u20130.75) for 1\u2010year, 0.61 (95% CI, 0.57\u20130.65) for 3\u2010year and 0.59 (95% CI, 0.55\u20130.62) for 5\u2010year survival. Across different subgroups, SI had the highest C\u2010index in men and women, limb onset and aged &lt;\u200960\u2009year ALS patients, compared with other indicators. However, cystatin C was the best indicator for predicting the survival of ALS patients with bulbar onset, whereas the prognostic nutritional index (PNI) was the best for those aged \u226560\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The serum SI demonstrates superior prognostic ability compared to other inflammation\u2010based, nutrition\u2010based and muscle mass\u2013related indicators for patients with ALS. Given its simplicity and availability, it is well suited for clinical use in evaluating the prognosis of ALS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13618","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:48:43Z","timestamp":1729817323000},"page":"2743-2755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prognostic Value of Systemic Inflammation, Nutritional Status and Sarcopenia in Patients With Amyotrophic Lateral Sclerosis"],"prefix":"10.1002","volume":"15","author":[{"given":"Yahui","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA  Beijing China"},{"name":"Department of Health Care, The Second Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiongming","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"College of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"College of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"College of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-0254","authenticated-orcid":false,"given":"Xusheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"issue":"5","key":"e_1_2_7_2_1","first-page":"1332","article-title":"Diagnosis and Clinical Management of Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders","volume":"23","author":"Goutman S. 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