{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:05:33Z","timestamp":1792616733263,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2014_Kolleg.05"],"award-info":[{"award-number":["2014_Kolleg.05"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008436","name":"Ernst und Berta Grimmke Stiftung","doi-asserted-by":"publisher","award":["5\/19"],"award-info":[{"award-number":["5\/19"]}],"id":[{"id":"10.13039\/501100008436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC2151\u2010390873048"],"award-info":[{"award-number":["EXC2151\u2010390873048"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has been shown that in patients with liver cirrhosis, sarcopenia is a predictor of acute decompensation (AD), acute\u2010on\u2010chronic liver failure (ACLF) and death. However, computer tomography (CT), as a suggested standard method for diagnosing sarcopenia, is resource intensive and involves radiation exposure. Therefore, in this study, we evaluate the muscle thickness of quadriceps femoris measured by ultrasound (US) as a prognostic parameter for AD and all\u2010cause mortality in chronic liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010three patients with chronic liver disease and signs of portal hypertension were analysed in this prospective monocentric study for the occurrence of acute decompensation such as hepatic encephalopathy, ascites, haemorrhage and liver\u2010related death within 1\u2009year. We assessed muscle thickness at three different heights in terms of suitability as a predictor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all 63 patients, 15 patients experienced acute decompensation, and 9 patients died due to liver\u2010related death. We found the upper third of the muscle, measured without applying pressure with the transducer, to be the most significant for predicting AD\/ACLF [AUC 0.739 (confidence interval (CI) 0.604\u20130.874, <jats:italic>p<\/jats:italic>\u2009=\u20090.006]. A cut\u2010off value of US\u2010defined muscle thickness standardized per height for identifying sarcopenia was determined (1.83\u2009cm\/m). Patients with US\u2010defined sarcopenia showed significantly higher rates of AD (38.9% vs. 3.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and all\u2010over 1\u2010year mortality (27.8% vs. 3.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.013). The mean AD free survival time is 8.3\u2009months (95% CI 6.6\u20139.9) for sarcopenic patients and 11.8\u2009months (95% CI 11.0\u201312.6) for the non\u2010sarcopenic cohorts. Corresponding CT analysis displayed similar results for AD free survival for both groups (40% AD rate in the sarcopenic group vs. 7% AD rate in the non\u2010sarcopenic group, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). The risk for AD was significantly higher in the sarcopenic cohort compared with those without sarcopenia in both US and CT (US: HR 16.6; <jats:italic>p<\/jats:italic>\u2009=\u20090.009; 95% CI 2.0\u2013136.0; CT: HR 8.7; <jats:italic>p<\/jats:italic>\u2009=\u20090.017; 95% CI 1.5\u201351.0). CT and US displayed a moderate agreement (<jats:italic>p<\/jats:italic>\u2009=\u20090.006; \u03ba\u2009=\u20090.379).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenia classification based on US measurements is shown to be an independent predictor of AD occurrence within 1\u2009year. This pilot study is the first to suggest that screening for sarcopenia by ultrasonography may be useful for risk assessment in patients with chronic liver disease and signs of portal hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.13630","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T05:07:20Z","timestamp":1731388040000},"page":"2792-2802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ultrasound\u2010Defined Sarcopenia Independently Predicts Acute Decompensation in Advanced Chronic Liver Disease"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-4241","authenticated-orcid":false,"given":"Juliana","family":"G\u00f6diker","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara\u00a0Noemi","family":"Reinartz\u00a0Groba","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kimmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn\u00a0Arne","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Henrik","family":"Peiffer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B University Hospital M\u00fcnster  M\u00fcnster 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