{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:25:44Z","timestamp":1784035544460,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112\u20102917\u2010I\u2010564\u2010036"],"award-info":[{"award-number":["NSTC 112\u20102917\u2010I\u2010564\u2010036"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inconsistent results have been reported concerning the association between statin administration and muscle health, specifically its potential to increase the risk of sarcopenia. Given the widespread long\u2010term use of statins among the elderly population, the exploration of this association remains a crucial yet insufficiently examined matter. This study aimed to assess the association between the prolonged administration of statins and the risk of sarcopenia, diminished muscle strength, reduced skeletal muscle mass and impaired physical performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This population\u2010based cohort study was conducted in Japan utilizing data derived from the National Institute for Longevity Sciences\u2010Longitudinal Study of Aging (NILS\u2010LSA). The study participants, enlisted from the 2nd to the 6th waves (spanning from April 2000 to July 2010) of NILS\u2010LSA, were those who aged 40\u2009years or older and had initiated statin therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009348, age: 64.1\u2009years, female: 63.5%). Individuals who were not administered statins (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092559, age: 55.5\u2009years, female: 48.4%) were arbitrarily chosen using a combined approach of propensity score (PS) matching and risk set sampling to form the control group (with a 1:4 matching ratio). The primary outcome of this study was the occurrence of sarcopenia, as defined by the 2019 consensus of the Asian Working Group for Sarcopenia (AWGS). The secondary outcomes included low muscle mass (&lt;\u20097.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      for men and below 5.4\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      for women by DXA), reduced skeletal muscle strength (handgrip strength\u2009&lt;\u200928\u2009kg in men and &lt;\u200918\u2009kg in women) and subpar physical performance (6\u2010min walking speed\u2009&lt;\u20091.0\u2009m\/s). The relationship between the use of statins and the outcomes was estimated using a Cox proportional hazard model with time\u2010varying covariates, which included the status of statin use and other variables (two\u2010tailed\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 was considered statistically significant). Stratification based on age and sex, along with five sensitivity analyses\u2014including propensity score overlap weighting and a negative control\u2014was conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After applying PS matching, we identified 342 statin initiators and 1294 non\u2010statin users, with well\u2010balanced baseline characteristics between the groups. The use of statins was not associated with an increased risk of incident sarcopenia (adjusted hazard ratio [aHR], 1.43 [95% CI, 0.86, 2.36]), diminished muscle strength (aHR, 1.11 [95% CI, 0.80, 1.54]), reduced muscle mass (aHR, 1.09 [95% CI, 0.66, 1.82]) or impaired physical performance (aHR, 0.73 [95% CI, 0.46, 1.17]). These findings were consistent across age and sex stratifications, as well as all sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Statin use was not associated with an elevated risk of sarcopenia or impaired muscle health among community\u2010dwelling middle\u2010aged and older adults in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13660","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:14:09Z","timestamp":1734322449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Risk of Sarcopenia Following Long\u2010Term Statin Use in Community\u2010Dwelling Middle\u2010Aged and Older Adults in Japan"],"prefix":"10.1002","volume":"16","author":[{"given":"Shih\u2010Tsung","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Center for Healthy Longevity and Aging Sciences National Yang Ming University  Taipei Taiwan"},{"name":"Department of Epidemiology of Aging, Research Institute National Center for Geriatrics and Gerontology  Obu Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Aging, Research Institute National Center for Geriatrics and Gerontology  Obu Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nishita","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Aging, Research Institute National Center for Geriatrics and Gerontology  Obu Aichi 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