{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:55:47Z","timestamp":1788537347452,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP2024R21"],"award-info":[{"award-number":["RSP2024R21"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While physical activity (PA) is known to reduce mortality in the general population, this relationship in individuals with multimorbidity (\u2265\u20092 chronic conditions) is unclear. This longitudinal study aimed to investigate whether there is a long\u2010term association between PA levels and mortality rates over a 12\u2010year period in adults with multimorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were obtained from eight waves of the Survey of Health, Ageing and Retirement in Europe (SHARE), from 28 European countries. PA levels were self\u2010reported via computer\u2010assisted personal interviews. Mortality during the follow\u2010up period was assessed using data obtained from caregivers through end\u2010of\u2010life interview. Multimorbidity was identified based on the presence of two or more 15 self\u2010reported chronic diseases\/conditions. Cox's regression analysis, adjusted for potential confounders, was used to assess the association between PA level and mortality.\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values were calculated using the Jonckheere\u2013Terpstra test for continuous variables and the Mantel\u2013Haenszel Chi\u2010square test for categorical variables, stratified by PA level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 9216 participants with multimorbidity (mean age 69\u2009\u00b1\u200910.1\u2009years; 58.7% were women). Among those with multimorbidity, individuals with high PA level were significantly younger, more frequently men, less impaired in activities of daily living, less educated and less frequently obese than those with very low level of PA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001 for all comparisons). Over the 12\u2009years of follow\u2010up, mortality incidence was three times higher in individuals with multimorbidity and very low PA levels than those with multimorbidity and high levels of PA. After adjusting for confounders, the risk of mortality was significantly lower for participants with moderately low PA levels (HR\u2009=\u20090.64; 95% CI: 0.59\u20130.71;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), moderately high PA levels (HR\u2009=\u20090.53; 95% CI: 0.47\u20130.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and high PA levels (HR\u2009=\u20090.49; 95% CI: 0.43\u20130.55;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) compared to those with very low PA levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings from the present study suggest that people with multimorbidity who had lower levels of PA were three times more likely to die prematurely after 12\u2009years than adults with multimorbidity and higher levels of PA at baseline. These findings underscore the importance of promoting physical activity in adults with multimorbidity to reduce the risk of premature mortality. Future longitudinal research is required to confirm\/refute our findings. Further, intervention studies are needed to understand whether increasing levels of physical activity in this population subsequently reduces mortality risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13695","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T02:26:42Z","timestamp":1738808802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010Term Impact of Physical Activity on Mortality in Adults With Multimorbidity: A 12\u2010Year Cohort Longitudinal Study From the Survey on Health, Ageing and Retirement in Europe"],"prefix":"10.1002","volume":"16","author":[{"given":"Nicola","family":"Veronese","sequence":"first","affiliation":[{"name":"Geriatric Unit, Department of Internal Medicine and Geriatrics University of Palermo  Palermo Italy"},{"name":"Biochemistry Department, College of Science King Saud University  Riyadh Saudi 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