{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:06:10Z","timestamp":1793307970582,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81960086"],"award-info":[{"award-number":["NSFC 81960086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160089"],"award-info":[{"award-number":["82160089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have demonstrated that metabolic score for visceral fat (METS\u2010VF), a novel surrogate indicator assessing visceral fat, was associated with the risk of hypertension, diabetes mellitus, cardiovascular disease (CVD) and mortality, predicting the risks based on a single METS\u2010VF measurement can increase limitations of the study. Few studies have investigated the association between cumulative exposure to METS\u2010VF and risk of CVD and all\u2010cause mortality. We aimed to examine the association of cumulative METS\u2010VF with risk for CVD and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All participants in the study were from the Kailuan Study, which is a large, prospective cohort study, and began in 2006\u2009years. Cumulative METS\u2010VF was calculated by data from 2006 survey to 2010 survey and defined as the mean METS\u2010VF for each pair of consecutive surveys multiplied by the time intervals between these two consecutive surveys. The optimal cut\u2010off value for time\u2010averaged cumulative METS\u2010VF associated with CVD was determined using a survival\u2010time method to calculate maximally selected rank statistics and was used to assess exposure of high METS\u2010VF. A multivariate Cox proportional hazards regression model was used to assess the risk of CVD and all\u2010cause mortality during 2010\u20132022\u2009years (hazard ratio [HR] and 95% confidence interval [95% CI]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 41\u2009756 participants (mean age, [52.72\u2009\u00b1\u200911.64] years, 78.53% males and 21.47% females). All participants were divided into four groups: Q1 (reference group), Q2, Q3 and Q4 according to the quartiles of cumulative METS\u2010VF, and exposure duration of high METS\u2010VF was quantified as 0, 2, 4, and 6\u2009years. During the median follow\u2010up of 12.01\u2009years, 4008 (9.60%) CVD events and 3944 all\u2010cause mortality events occurred. After adjusting for potential covariates, compared to participants in Q1 group, the HRs of incident CVD and all\u2010cause mortality were 1.55 (95% CI, 1.38\u20131.74) and 1.59 (95% CI, 1.40\u20131.81) for those in Q2 group, 2.13 (95% CI, 1.91\u20132.38) and 2.67 (95% CI 2.37\u20133.01) for those in Q3 group, 2.78 (95% CI, 2.49\u20133.17) and 4.90 (95% CI 4.36\u20135.50) for those in Q4 group. The HRs for CVD and all\u2010cause mortality were increased with exposure duration of high METS\u2010VF increasing. The result of ROC curve analysis showed that cumulative METS\u2010VF had the highest predictive for CVD among 4 indexes including cumulative METS\u2010VF, cumulative waist circumference, cumulative body mass index and cumulative WHtR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high cumulative METS\u2010VF was associated with an increased risk of CVD and mortality, and this association was stronger as exposure to high METS\u2010VF was prolonged, emphasizing the importance of striving to control the METS\u2010VF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13702","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T02:55:23Z","timestamp":1739328923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Association of Cumulative Exposure to Metabolic Score for Visceral Fat With the Risk of Cardiovascular Disease and All\u2010Cause Mortality: A Prospective Cohort Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Qian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology Lanzhou University Second Hospital  Lanzhou China"},{"name":"The Second Clinical Medical School Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhe","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lanzhou University Second Hospital  Lanzhou China"},{"name":"The Second Clinical Medical School Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-764X","authenticated-orcid":false,"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lanzhou University Second Hospital  Lanzhou China"},{"name":"The Second Clinical Medical School Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02750-2"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.02.003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6483.1692"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30084-1"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.07.012"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110842"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020180"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.01.045"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.4758"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.042525"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0610"},{"key":"e_1_2_13_15_1","first-page":"83","article-title":"Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults\u2013Study on Optimal Cut\u2010Off Points of Body Mass Index and Waist Circumference in Chinese Adults","volume":"15","author":"Zhou B. 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