{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:48:06Z","timestamp":1792129686600,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102023R1A2C3006220"],"award-info":[{"award-number":["NRF\u20102023R1A2C3006220"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1A5A8029876"],"award-info":[{"award-number":["NRF\u20102021R1A5A8029876"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102020R1C1C1008033"],"award-info":[{"award-number":["NRF\u20102020R1C1C1008033"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age\u2010related primary sarcopenia and end\u2010stage renal disease (ESRD)\u2013related muscle wasting are discrete entities; however, both manifest as a decline in skeletal muscle mass and strength. The etiological pathways differ, with aging factors implicated in sarcopenia and a combination of uremic factors, including haemodialysis, contributing to ESRD\u2010related muscle wasting. Understanding these molecular nuances is imperative for targeted interventions, and the integration of proteomic and metabolomic data elucidate these intricate processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We generated detailed clinical data and multi\u2010omics data (plasma proteomics and metabolomics) for 78 participants to characterise sarcopenia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928; mean age, 72.6\u2009\u00b1\u20097.0\u2009years) or ESRD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922; 61.6\u2009\u00b1\u20095.5\u2009years) compared with controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928; 69.3\u2009\u00b1\u20095.7\u2009years). Muscle mass was measured using bioelectrical impedance analysis and handgrip strength. Five\u2010times sit\u2010to\u2010stand test performance was measured for all participants. Sarcopenia was diagnosed in accordance with the 2019 Consensus Guidelines from the Asian Working Group for Sarcopenia. An abundance of 234 metabolites and 722 protein groups was quantified in all plasma samples using liquid chromatography with tandem mass spectrometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Muscle mass, handgrip strength and lower limb muscle function significantly lower in the sarcopenia group and the ESRD group compared with those in the control group. Metabolomics revealed altered metabolites, highlighting exclusive differences in ESRD\u2010related muscle wasting. Metabolite set enrichment analysis revealed the involvement of numerous metabolic intermediates associated with urea cycle, amino acid metabolism and nucleic acid metabolism. Catecholamines, including epinephrine, dopamine and serotonin, are significantly elevated in the plasma of patients within the ESRD group. Proteomics data exhibited a clearer distinction among the three groups compared with the metabolomics data, particularly in distinguishing the control group from the sarcopenia group. The ciliary neurotrophic factor receptor was top\u2010ranked in terms of the variable importance of projection scores. Plasma AHNAK protein levels was higher in the sarcopenia group but was lower in the ESRD group. Proteomic set enrichment analysis revealed enrichment of several pathways related to sarcopenia, such as hemopexin, defence response and cell differentiation, in sarcopenia group. Multi\u2010omic integration analysis revealed associations between relevant metabolites, including catecholamines, and a group of annotated proteins in extracellular exosomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified distinct multi\u2010omic signatures in individuals with ESRD or sarcopenia, providing new insights into the mechanisms underlying ESRD\u2010related muscle wasting, which differ from primary sarcopenia. These findings may support interventions for context\u2010dependent muscle loss and contribute to the development of targeted treatments and preventive strategies for muscle wasting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13749","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:39:31Z","timestamp":1744259971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparative Analysis of Primary Sarcopenia and End\u2010Stage Renal Disease\u2013Related Muscle Wasting Using Multi\u2010Omics Approaches"],"prefix":"10.1002","volume":"16","author":[{"given":"Daiki","family":"Setoyama","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine Kyushu University Hospital  Fukuoka 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