{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:02:56Z","timestamp":1775851376123,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of lobectomy versus segmentectomy on body composition changes, particularly adipose tissue, in patients with early\u2010stage lung cancer remains unclear. This study aimed to determine the association between these surgical approaches and postoperative changes in adipose tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analysed visceral fat area (VFA) and waist circumference (WC) at the L3 level using cross\u2010sectional computed tomography images from 346 recurrence\u2010free patients who underwent lobectomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009240) or segmentectomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106) for clinical stage 0\u2013I primary lung cancer between January 2016 and December 2018. Long\u2010term postoperative changes in VFA and WC by the third postoperative year (POY3) were compared between the lobectomy and segmentectomy groups using two\u2010way repeated measures analysis of variance (ANOVA). Risk factors for VFA reduction were identified through multivariable analysis using logistic regression model. Propensity score matching (PSM, 1:1 matching) was also performed to compare VFA and WC changes between the lobectomy and segmentectomy groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 6\u2009months postoperatively, VFA and WC decreased by 16.4% and 1.0% in the lobectomy groups, respectively, and increased by 0.1% and 0.2% in the segmentectomy groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029, respectively). The two\u2010way repeated measure ANOVA showed that the VFA and WC significantly decreased in the lobectomy group compared with the segmentectomy group within the POY3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038, respectively). Patients with a VFA change of \u2265\u2009\u221213% at POY3 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009238) had significantly better OS than those with a change of &lt;\u2009\u221213% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009108) (5\u2010year OS rate, 97.7% vs. 93.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), and VFA change &lt;\u2009\u221213% at POY3 was an independent poor prognostic factor for OS (hazard ratio, 4.14;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). Lobectomy was identified as an independent risk factor for a VFA change of &lt;\u2009\u221213% at POY3 (odds ratio, 2.86;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After PSM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993 for each group), VFA and WC significantly decreased in the lobectomy group compared with the lobectomy group within the POY3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with early\u2010stage lung cancer without recurrence, long\u2010term postoperative changes in VFA and WC differed between lobectomy and segmentectomy. Lobectomy resulted in a greater decrease in VFA from 6\u2009months to 3\u2009years postoperatively. In contrast, segmentectomy was associated with neither long\u2010term postoperative VFA nor WC reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13751","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:45:31Z","timestamp":1741740331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early\u2010Stage Lung Cancer"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-7133","authenticated-orcid":false,"given":"Tetsuya","family":"Isaka","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Washimi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Narimatsu","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine Kanagawa Cancer Center  Yokohama Kanagawa Japan"},{"name":"Cancer Prevention and Cancer Control Division Kanagawa Cancer Center Research Institute  Yokohama Kanagawa Japan"},{"name":"Graduate School of Health Innovation Kanagawa University of Human Services  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Shigefuku","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryotaro","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Sueishi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanagawa Cancer Center  Yokohama Kanagawa 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