{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:35:10Z","timestamp":1792661710353,"version":"4.5.0"},"reference-count":89,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000248157"],"award-info":[{"award-number":["RS\u20102023\u201000248157"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Numerous studies support the association of exercise training, physical activity (PA) and sedentary behaviour (SB) with both mortality and morbidity outcomes. The results across studies have been inconsistent, and no umbrella reviews have yet been conducted on this topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an umbrella review of meta\u2010analyses of observational studies by screening articles in PubMed\/MEDLINE, EMBASE and Web of Science databases from inception to 30 April 2024. Quality appraisal of each included meta\u2010analysis was done using the AMSTAR 2 tool, with evidence certainty evaluated based on statistical significance, study size, heterogeneity, small\u2010study effects, prediction intervals (PI) and potential biases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Frothy\u2010eight meta\u2010analyses were included (AMSTAR 2 ratings: high 25, moderate 10, low 2 and critically low 11). No evidence was highly suggestive or convincing. Suggestive evidence linked any PA and SB to lower and higher risks of all\u2010cause, cardiovascular and cancer mortality. Suggestive evidence indicated a significant association between self\u2010reported and device\u2010measured total PA (equivalent odds ratio [eOR] 0.78 [0.70\u20130.86] and eHR\u2009=\u20090.50 [0.38\u20130.65], respectively), self\u2010reported leisure time PA (eHR\u2009=\u20090.73 [0.66\u20130.80]), device\u2010measured daily steps (eHR\u2009=\u20090.44 [0.35\u20130.56]) and aerobic plus resistance training (eHR\u2009=\u20090.60 [0.56\u20130.64]) with lower all\u2010cause mortality. Weak evidence supported links between self\u2010reported and device\u2010measured SB and higher mortality (eHR\u2009=\u20091.3 [1.22\u20131.38] and eHR\u2009=\u20092.16 [1.09\u20134.28], respectively). Suggestive evidence was noted for the association between self\u2010reported leisure time PA (eHR\u2009=\u20090.74 [0.69\u20130.80]) and resistance training (eHR\u2009=\u20090.82 [0.81\u20130.84]) with cardiovascular mortality. Suggestive evidence was also found for the association between self\u2010reported leisure time PA (eHR\u2009=\u20090.87 [0.83\u20130.91]) with cancer mortality. Associations between self\u2010reported running time and mortality from all causes, cardiovascular diseases (CVD) and cancer did not reach statistical significance nor did the association between low skeletal muscle mass and all\u2010cause mortality. Meta\u2010regression analyses showed that physical activity reduces mortality risk, with age reducing the protective effects against all\u2010cause, CVD and cancer mortality. We also found that combined exercise training (aerobic plus resistance) most effectively reduces all\u2010cause and CVD mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Converging evidence supports that physical activity and sedentary behaviour are associated with lower and higher rates of all\u2010cause, cardiovascular and cancer mortality. More high\u2010quality prospective studies are needed for a better understanding of the associations between running time and also TV\u2010viewing time and health\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13772","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:53:34Z","timestamp":1741758814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta\u2010Analyses"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-027X","authenticated-orcid":false,"given":"Masoud","family":"Rahmati","sequence":"first","affiliation":[{"name":"CEReSS\u2010Health Service Research and Quality of Life Center, Assistance Publique\u2010Hopitaux de Marseille Aix\u2010Marseille University  Marseille 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Humanities Vali\u2010E\u2010Asr University of Rafsanjan  Rafsanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Boyer","sequence":"additional","affiliation":[{"name":"CEReSS\u2010Health Service Research and Quality of Life Center, Assistance Publique\u2010Hopitaux de Marseille Aix\u2010Marseille University  Marseille France"},{"name":"CRSMP, Center for Mental Health and Psychiatry Research \u2013 PACA  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Fond","sequence":"additional","affiliation":[{"name":"CEReSS\u2010Health Service Research and Quality of Life Center, Assistance Publique\u2010Hopitaux de Marseille Aix\u2010Marseille University  Marseille France"},{"name":"CRSMP, Center for Mental Health and Psychiatry Research \u2013 PACA  Marseille 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