{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:42:45Z","timestamp":1791909765766,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To date, most research investigating the influence of circulating sex hormones on ageing female skeletal muscle has been cross\u2010sectional and focused only on dichotomised young and old, or pre\u2010 versus post\u2010menopausal groups. This excludes an important transitional period from high to low circulating oestrogen. Using secondary data from the Baltimore Longitudinal Study of Aging, this study aimed to investigate cross\u2010sectional and longitudinal associations between circulating sex hormones and skeletal muscle mass and function across a continuum of ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Multiple and binomial linear regression was used to map cross\u2010sectional (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009319) and longitudinal (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200983) associations between circulating sex hormones (oestradiol (E2), free oestradiol index (FEI), total (TT) and bioavailable (BioT), testosterone, testosterone\/oestradiol ratio (TT\/E2)) and skeletal muscle mass and function in healthy females. Cross\u2010sectional models analysed females across an ageing continuum (24\u201389\u2009years) and longitudinal associations were tested across 4\u20136\u2009years of ageing in females over 50\u2009years old. Models were adjusted for age, height, physical activity, comorbidities, ethnicity, and follow\u2010up time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cross\u2010sectionally, serum E2 and FEI were positively associated with relative appendicular lean mass (ALM; \u03b2\u2009=\u20090.28 and 0.20, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and thigh muscle percentage (\u03b2\u2009=\u20090.19 and 0.15, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). E2 and FEI were negatively associated with total body fat percentage (\u03b2\u2009=\u2009\u22120.30 and \u22120.21, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). BioT was positively associated with absolute ALM (\u03b2\u2009=\u20090.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and total body fat percentage (\u03b2\u2009=\u20090.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). TT was negatively associated with total body fat percentage (\u03b2\u2009=\u2009\u22120.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The TT\/E2 ratio was negatively associated with thigh muscle CSA (\u03b2\u2009=\u2009\u22120.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and hamstring strength (\u03b2\u2009=\u2009\u22120.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Across 4\u20136\u2009years, decreases in E2 and FEI were associated with a decrease in ALM (\u03b2\u2009=\u20090.27 and 0.41, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and a decrease in FEI was associated with a decrease in handgrip strength (\u03b2\u2009=\u20090.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Decreases in TT and BioT were associated with an increase in total body fat (\u03b2\u2009=\u2009\u22120.25 for both,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and a decrease in TT was associated with an increase in hamstring specific force (\u03b2\u2009=\u2009\u22120.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates novel associations between sex hormone levels and skeletal muscle in females across a wide continuum of ages. We also demonstrate that longitudinal fluctuations in circulating sex hormones must be considered to gain a comprehensive understanding of female muscle ageing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13786","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T01:40:38Z","timestamp":1745890838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-9528","authenticated-orcid":false,"given":"Annabel\u00a0J.","family":"Critchlow","sequence":"first","affiliation":[{"name":"School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition (IPAN) Deakin University  Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah\u00a0E.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Cardiometabolic Health and Exercise Physiology Baker Heart and Diabetes Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle\u00a0S.","family":"Hiam","sequence":"additional","affiliation":[{"name":"School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition (IPAN) Deakin University  Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"National Institute on Aging, National Institutes of Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Scott","sequence":"additional","affiliation":[{"name":"School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition (IPAN) Deakin University  Geelong Australia"},{"name":"School of Clinical Sciences at Monash Health Monash University  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3271-6551","authenticated-orcid":false,"given":"S\u00e9verine","family":"Lamon","sequence":"additional","affiliation":[{"name":"School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition (IPAN) Deakin University  Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization \u201cAgeing and Health \u201d (2024) accessed 22\/07\/2024 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/ageing\u2010and\u2010health."},{"key":"e_1_2_8_3_1","unstructured":"Australian Bureau of Statistics \u201cTwenty Years of Population Change \u201d (2020) accessed 22\/07\/2024 https:\/\/www.abs.gov.au\/articles\/twenty\u2010years\u2010population\u2010change."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31138-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615622537"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12043"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12783"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0081"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-00750-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155597"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz196"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215610589"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2021.1921854"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89232-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-022-01733-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2023.107844"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.3.330"},{"key":"e_1_2_8_19_1","volume-title":"Normal Human Aging: The Baltimore Longitudinal Study of Aging","author":"Shock N. 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