{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:31:10Z","timestamp":1790962270566,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) may influence musculoskeletal health. The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6\u2009weeks of aerobic exercise.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Nine\u2010week\u2010old male Wistar rats (\n n<\/jats:italic>\n \u2009=\u200980) were randomized to either exercise (EX) or no\u2010exercise control (CON) conditions and treated with naproxen, ibuprofen (IBU), flurbiprofen (FLU) or placebo (PLA). For exercise, rats ran 5\u2009days per week for 6\u2009weeks at a 5% incline on a motorized treadmill for 30\u2009min. Three\u2010point bending (3\u2009PB) and microcomputed tomography (microCT) were measured in the femur. Anabolic muscle signalling pathways were measured in the quadriceps. Muscle fibre cross\u2010sectional area (CSA) and fibre type were measured in the soleus. Data were analysed using a two\u2010way ANOVA for treatment by condition and is visualized as mean\u2009\u00b1\u2009standard deviation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n For 3\u2009PB, there was an exercise effect for ultimate bending energy, postyield energy, toughness, postyield toughness, postyield displacement, ultimate strain and postyield strain (all,\n p<\/jats:italic>\n \u2009<\u20090.05). There was a treatment by condition effect for Young's Modulus, where placebo exercise was less than placebo control (PLA EX: 3256.44\u2009\u00b1\u2009463.41\u2009MPa, PLA CON: 4849.94\u2009\u00b1\u2009836.70\u2009MPa,\n p<\/jats:italic>\n \u2009<\u20090.05). For microCT, there was a treatment by condition effect for trabecular thickness (\n p<\/jats:italic>\n \u2009=\u20090.047) and the IBU EX group increased thickness compared with the IBU CON group (IBU EX: 0.133\u2009\u00b1\u20090.011\u2009mm, IBU CON: 0.121\u2009\u00b1\u20090.007\u2009mm,\n p<\/jats:italic>\n \u2009=\u20090.027). In the quadriceps, for myosin heavy chain abundance, there was a treatment by condition effect (\n p<\/jats:italic>\n \u2009=\u20090.046) and ibuprofen exercise was lower than ibuprofen control (IBU EX: 0.636\u2009\u00b1\u20090.513\u2009AU, IBU CON: 1.81\u2009\u00b1\u20091.012\u2009AU,\n p<\/jats:italic>\n \u2009=\u20090.016). There was no treatment by condition effect for phosphorylation of the AKT, AMPK or ERK pathways (all,\n p<\/jats:italic>\n \u2009>\u20090.05). In the soleus, there was no treatment by condition effect for fibre type percentage or muscle CSA (\n p<\/jats:italic>\n \u2009>\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n NSAIDs did not have a strong negative or positive effect on musculoskeletal adaptations to 6\u2009weeks of treadmill running in young healthy male rodents.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcsm.13798","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:44:46Z","timestamp":1744332286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ibuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0395-6967","authenticated-orcid":false,"given":"Brandon\u00a0M.","family":"Roberts","sequence":"first","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"},{"name":"Sargent College of Health & Rehabilitation Sciences Boston University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa\u00a0V.","family":"Geddis","sequence":"additional","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ciuciu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinaliz","family":"Reynoso","sequence":"additional","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa\u00a0N.","family":"Varanoske","sequence":"additional","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"},{"name":"Oak Ridge Institute for Science and Education Belcamp Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa\u00a0M.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximus\u00a0C.","family":"Leiss","sequence":"additional","affiliation":[{"name":"Sargent College of Health & Rehabilitation Sciences Boston University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander\u00a0L.","family":"Kolb","sequence":"additional","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie\u00a0M.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall\u00a0A.","family":"Naimo","sequence":"additional","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan\u00a0E.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery\u00a0S.","family":"Staab","sequence":"additional","affiliation":[{"name":"Military Performance Division US Army Research Institute of Environmental Medicine Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e318291ba98"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-020-03581-y"},{"issue":"4","key":"e_1_2_11_4_1","first-page":"1243","article-title":"Muscle Injuries and Repair: The Role of Prostaglandins and Inflammation","volume":"18","author":"Prisk V.","year":"2003","journal-title":"Histology and Histopathology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.3.3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00091-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13275"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00088.2004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00518.2005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000218142.98704.66"},{"issue":"5","key":"e_1_2_11_11_1","first-page":"559","article-title":"Ibuprofen Administration During Endurance Training Cancels Running\u2010Distance\u2010Dependent Adaptations of Skeletal Muscle in Mice","volume":"61","author":"Machida M.","year":"2010","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15502783.2024.2302046"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15502783.2022.2164209"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000225"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(90)90081-U"},{"issue":"1","key":"e_1_2_11_16_1","first-page":"44","article-title":"Do Steroids, Conventional Non\u2010steroidal Anti\u2010Inflammatory Drugs and Selective Cox\u20102 Inhibitors Adversely Affect Fracture Healing?","volume":"9","author":"Boursinos L. A.","year":"2009","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679008993070"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1979.tb00893.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453679209169718"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(89)90145-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.04.009"},{"issue":"3","key":"e_1_2_11_22_1","first-page":"500","article-title":"Dose and Time\u2010Dependent Effects of Cyclooxygenase\u20102 Inhibition on Fracture\u2010Healing","volume":"89","author":"Simon A. M.","year":"2007","journal-title":"Journal of Bone and Joint Surgery American Volume"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/CBI20090211"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202302642R"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00619-6"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.01.009"},{"issue":"2","key":"e_1_2_11_27_1","first-page":"E287","article-title":"Indomethacin Has Distinct Early and Late Actions on Bone Formation Induced by Mechanical Stimulation","volume":"267","author":"Chow J. W.","year":"1994","journal-title":"American Journal of Physiology"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650111112"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-1025-y"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556658"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003553"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(88)90120-2"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9593-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001194"},{"issue":"1","key":"e_1_2_11_36_1","first-page":"78","article-title":"Bone Loss From High Repetitive High Force Loading Is Prevented by Ibuprofen Treatment","volume":"14","author":"Jain N. X.","year":"2014","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90874.2008"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01299.2013"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00423.2009"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00352.2001"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15481"}],"container-title":["Journal of Cachexia, Sarcopenia and Muscle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcsm.13798","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcsm.13798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T04:13:38Z","timestamp":1771215218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcsm.13798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jcsm.13798"],"URL":"https:\/\/doi.org\/10.1002\/jcsm.13798","archive":["Portico"],"relation":{},"ISSN":["2190-5991","2190-6009"],"issn-type":[{"value":"2190-5991","type":"print"},{"value":"2190-6009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13798"}}