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However, a significant side effect of cisplatin is muscle atrophy, which severely impairs physical strength, diminishes quality of life and complicates cancer therapy. Cisplatin\u2010induced muscle wasting arises from a complex interplay of enhanced proteolysis, reduced muscle protein synthesis and systemic inflammation. Understanding the underlying molecular mechanisms of muscle atrophy is vital for identifying new therapeutic targets. This review systematically explores molecular\u2010based therapies and plant\u2010derived natural compounds, providing a comprehensive overview of their efficacy in\u00a0vivo and in\u00a0vitro for preventing cisplatin\u2010induced muscle atrophy. Both molecular\u2010based therapies and plant\u2010derived natural compounds present promising strategies for mitigating cisplatin\u2010induced muscle atrophy. Ghrelin, growth hormone secretagogues and testosterone stimulate anabolic pathways and reduce muscle degradation, whereas natural compounds like capsaicin and naringenin exert protective effects by reducing inflammation and oxidative stress. A better understanding of the pathophysiology of muscle atrophy, combined with optimized therapeutic applications, may facilitate the clinical translation of these interventions to improve outcomes for cancer patients undergoing chemotherapy.<\/jats:p>","DOI":"10.1002\/jcsm.13817","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T03:40:54Z","timestamp":1746675654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cisplatin\u2010Induced Muscle Wasting and Atrophy: Molecular Mechanism and Potential Therapeutic Interventions"],"prefix":"10.1002","volume":"16","author":[{"given":"Ko\u2010Chieh","family":"Huang","sequence":"first","affiliation":[{"name":"School of Nutrition and Health Sciences, College of Nutrition Taipei Medical University  Taipei 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