{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:26Z","timestamp":1786978046557,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNSF 32473B_156978"],"award-info":[{"award-number":["SNSF 32473B_156978"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_188886"],"award-info":[{"award-number":["320030_188886"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Muscle strength, mass and function have been associated with falls, fractures and mortality, but the results vary between previous studies. We aimed to investigate the predictive ability of muscle strength and mass with 10\u2010year incident fragility fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 1475 postmenopausal women aged 50\u201380\u2009years (OsteoLaus cohort, Lausanne, Switzerland). Handgrip strength (HGS) was assessed. With a Jamar dynamometer and lean mass (LM) with dual x\u2010ray absorptiometers (DXA) every 2.5\u2009years for 10\u2009years. LM, appendicular lean mass (ALM) and their indexes were assessed following the International Society for Clinical Densitometry (ISCD) guidelines. Main outcomes included hip, humerus and forearm low\u2010trauma fractures from in\u2010person interviews and vertebral fracture (VF) from lateral DXA screening. Secondary outcomes included falls and death. Baseline values were compared using two\u2010sided\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test or Wilcoxon test (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0029 based on Bonferroni). Multivariate analysis included time to fracture with accelerated failure time (AFT) model and odds ratio (OR) with logistic regression, 95% confidence interval (CI) and C\u2010Index or AUC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 10.2\u2009\u00b1\u20090.4\u2009years of follow\u2010up, 944 women remained enrolled (age 73.0\u2009\u00b1\u20096.9\u2009years, BMI 25.7\u2009\u00b1\u20094.8\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , ALM 16.8\u2009\u00b1\u20092.5\u2009kg, HGS 21.2\u2009\u00b1\u20095.5\u2009kg), of whom 260 fractured (174 VF, 107 non\u2010VF), 863 fell and 74 died. Participants with an incident fragility fracture had a 1.5\u2010kg lower HGS at baseline but no significant difference in their ALM, ALM\/height\n                      <jats:sup>2<\/jats:sup>\n                      and ALM\/BMI compared to nonfractured participants. In the multivariable models, one SD increase in ALM (+2.58\u2009kg) was associated with a 0.72 (CI:0.61\u20130.85) and 0.67 (CI:0.55\u20130.82) shorter time to major osteoporotic fractures (MOF) and VF. While ALM\/BMI was associated with a 1.26 (CI:1.01\u20131.59) and 1.98 (CI:1.21\u20133.25) longer time to MOF and non\u2010VF. One SD increase in HGS was associated with a 1.37 (CI:1.03\u20131.81) longer time to non\u2010VF only. A careful consideration of body weight and fat mass is needed in the association of lean mass with fractures. Baseline muscle parameters were not different for participant with or without incident fall or death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lean mass and grip strength appear as independent risk factors for incident MOF, but with limited additional prediction performance. The prediction of fragility fractures differs between the fracture sites. Further studies with larger sample size, other muscle assessment modalities considering weight or fat mass as covariate, and broader ethnicities are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.13837","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:01:06Z","timestamp":1749016866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prediction of 10\u2010Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-7279","authenticated-orcid":false,"given":"Colin","family":"Vendrami","sequence":"first","affiliation":[{"name":"Interdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"},{"name":"Department of Medicine, Internal Medicine Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-6008","authenticated-orcid":false,"given":"Elena","family":"Gonzalez\u00a0Rodriguez","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-391X","authenticated-orcid":false,"given":"Guillaume","family":"Gatineau","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-896X","authenticated-orcid":false,"given":"Peter","family":"Vollenweider","sequence":"additional","affiliation":[{"name":"Department of Medicine, Internal Medicine Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-8500","authenticated-orcid":false,"given":"Pedro","family":"Marques\u2010Vidal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Internal Medicine Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-2376","authenticated-orcid":false,"given":"Olivier","family":"Lamy","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"},{"name":"Department of Medicine, Internal Medicine Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-5958","authenticated-orcid":false,"given":"Didier","family":"Hans","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-2948","authenticated-orcid":false,"given":"Enisa","family":"Shevroja","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"OECD \u201cEuropean Union. Health at a Glance: Europe 2022: State of Health in the EU Cycle [Internet] \u201d OECD; (2022) (Health at a Glance: Europe) retrieved March 10 2024 https:\/\/www.oecd\u2010ilibrary.org\/social\u2010issues\u2010migration\u2010health\/health\u2010at\u2010a\u2010glance\u2010europe\u20102022_507433b0\u2010en."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-020-00871-9"},{"key":"e_1_2_8_4_1","unstructured":"World Health Organization (WHO) \u201cAssessment of Fracture Risk and Its Application to Screening for Postmenopausal Osteoporosis : Report of a WHO Study Group [Meeting Held in Rome From 22 to 25 June 1992] [Internet] \u201d World Health Organization (1994) retrieved July 24 2020 https:\/\/apps.who.int\/iris\/handle\/10665\/39142."},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-068033","article-title":"Fracture Risk Reduction and Safety by Osteoporosis Treatment Compared With Placebo or Active Comparator in Postmenopausal Women: Systematic Review, Network Meta\u2010Analysis, and Meta\u2010Regression Analysis of Randomised Clinical Trials","volume":"2","author":"H\u00e4ndel M. 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