{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:04:06Z","timestamp":1792202646021,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["MP0022856"],"award-info":[{"award-number":["MP0022856"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002989","name":"Descartes Centre voor Wetenschapsgeschiedenis en Wetenschapsfilosofie, Universiteit Utrecht","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013226","name":"Les Laboratories Pierre Fabre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biological clocks are promising tools for the evaluation of biological age deviations (i.e., positive\/negative acceleration). Here, we explored the associations of biological age acceleration (BAA) assessed by Horvath's, Hannum's, PhenoAge, and GrimAge epigenetic clocks, as well as the iAge inflammation\u2010based clock, with functional capacities across adulthood and tested if chronological age and sex moderate these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional analysis was conducted with baseline (2019\u20132021) data from 1014 participants (age range 20\u2013104\u2009years old, 62.82% female) drawn from the Inspire Translational Human cohort, a community\u2010based program in South\u2010West France. Physical capacity endpoints included the five\u2010time sit\u2010to\u2010stand test (5\u2010STS), the Short Physical Performance Battery (SPPB), the 30\u2010s chair stand test (30\u2010s CST), maximum oxygen uptake (VO2max) and isokinetic muscle strength (IMS). Multivariate linear regression was used to explore the associations of BAA (with and without interacting with chronological age or sex) with functional capacity endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1014 individuals with available data on BAA and functional capacities were included (median age 64, IQR\u2009=\u200949\u201378, 62.82% female). GrimAge was the clock that more strongly correlated with functional capacities. Higher GrimAge BAA was associated with worse 5\u2010STS (\u03b2\u2009=\u20090.25, 95% CI\u2009=\u20090.07, 0.43;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), SPPB (\u03b2\u2009=\u2009\u22120.10, 95% CI\u2009=\u2009\u22120.18, \u22120.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019) and VO2max (\u03b2\u2009=\u2009\u22121.17, 95% CI\u2009=\u2009\u22121.81, \u22120.52;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) across the whole adulthood. When the moderation effect of age was explored, BAA acceleration assessed by GrimAge was associated with worse 30\u2010s CST in early adulthood. Increased iAge BAA was associated with poor SPPB and 5\u2010STS at older age, whereas Horvath's BAA correlated with a decline in 30\u2010s CST.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among four DNA methylation epigenetic clocks and one inflammatory clock, our study shows that GrimAge is the biological ageing clock that best associates with different measures of functional capacity, from young to older adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70046","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T09:17:08Z","timestamp":1755249428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE\u2010T Cohort"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-6015","authenticated-orcid":false,"given":"Juan\u00a0Luis","family":"S\u00e1nchez\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR1295 University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"CERPOP UMR1295 University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bensadoun","sequence":"additional","affiliation":[{"name":"INSERM IRMB UMR1183, H\u00f4pital Saint Eloi Universit\u00e9 de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"INSERM IRMB UMR1183, H\u00f4pital Saint Eloi Universit\u00e9 de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Fuentealba\u00a0Valenzuela","sequence":"additional","affiliation":[{"name":"Buck Artificial Intelligence Platform, the Buck Institute for Research on Ageing  Novato USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Pillard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9decine du Sport, Clinique Universitaire du Sport, H\u00f4pital Pierre Paul RIQUET (Centre Hospitalo\u2010Universitaire)  Toulouse France"},{"name":"Centre RESTORE (Geroscience and Rejuvenation Center), UMR1301 (INSERM)\/UMR5070 (CNRS)  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR1295 University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Furman","sequence":"additional","affiliation":[{"name":"Buck Artificial Intelligence Platform, the Buck Institute for Research on Ageing  Novato USA"},{"name":"Stanford 1000 Immunomes Project Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipe","family":"de Souto\u00a0Barreto","sequence":"additional","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR1295 University of Toulouse III, Inserm, UPS  Toulouse 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Associated With Clinical, Immunological and Lifestyle Factors","author":"Fuentealba M.","year":"2024","journal-title":"bioRxiv"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu277"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016708"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01094-6"},{"key":"e_1_2_7_32_1","first-page":"504","article-title":"DNA Methylation Age and Physical and Cognitive Ageing","volume":"75","author":"Maddock J.","year":"2020","journal-title":"Journals of Gerontology \u2013 Series A Biological Sciences and Medical 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