{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:39:43Z","timestamp":1788997183748,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Unlike most malignancies, increased adiposity, as expressed by a higher body mass index (BMI), is associated with improved prognosis after lung cancer surgery at the population level. Height, one of the determinants of BMI, is associated with better survival, independent of other confounders, even though BMI is calculated as weight divided by height squared. The association of weight with survival is difficult to assess because, at the individual level, weight is closely linked to height and does not directly reflect adiposity. In this study, we examined the impact of height and weight on overall survival in a large population of patients undergoing upfront surgery for lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted data on all consecutive patients with stage I\u2013IIIA non\u2010small cell lung cancer included in a surgical nationwide dataset over a 16\u2010year period. For each sex, height was categorised in sex\u2010specific quartiles (sH). Sex\u2010specific height\u2010normalised weight (sHNW) was defined as the ratio of an individual's weight to the mean weight of individuals of the same sex and height, and it was categorised into quartiles. Finally, the sum of the category membership (ranging from 1 to 4 according to quartiles) of sH and sHNW was calculated, and the results were categorised into four groups of sH\/sHNW. Overall survival (OS) was assessed by Kaplan\u2013Meier, and differences evaluated by log\u2010rank. Cox models were built.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 50\u2009653 patients. Mean age was 65.61\u2009\u00b1\u20099.45 and 31.99% were women. sH predicted OS, taller height being protective [crude HRs of second, third, and fourth quartiles vs. first quartile: 0.94 (95% CI 0.91\u20130.98), 0.89 (0.86\u20130.92), 0.77 (0.74\u20130.81); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001]. sHNW was also associated with OS, with lower sHNW category being associated with worse outcome and higher sHNW categories being protective [crude HRs of second, third and fourth quartiles vs. first quartile: 0.88 (0.85\u20130.92), 0.82 (0.79\u20130.85), 0.85 (0.81\u20130.88); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001]. The four classes of sH\/sHNW showed higher differences in prognosis with respective crude HRs of 0.88 (0.84\u20130.93), 0.76 (0.73\u20130.80) and 0.70 (0.66\u20130.74) in the intermediate lower, intermediate higher and higher class as compared with the lower class. Five\u2010year overall survival rates were 58.65% (56.89\u201360.45), 62.96% (62.15\u201363.78), 67.71% (67.02\u201368.41) and 70.12% (68.98\u201371.26), in the lower, intermediate lower, intermediate higher and higher class, respectively. All Cox models showed that sHNW and sH\/sHNW predicted survival independently from common confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that sHNW and sH\/sHNW are strong prognostic factors of resectable lung cancer. This finding could have both epidemiologic and biological relevance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcsm.70049","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T03:50:47Z","timestamp":1755575447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Beyond Body Mass Index: The Impact of Height and Height\u2010Normalised Weight on Overall Survival of Lung Cancer Undergoing Surgery"],"prefix":"10.1002","volume":"16","author":[{"given":"Lorenzo","family":"Gherzi","sequence":"first","affiliation":[{"name":"Thoracic Surgery Department Cochin Hospital, University of Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Prieto","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department Cochin Hospital, University of Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Iannelli","sequence":"additional","affiliation":[{"name":"University of Nice C\u00f4te d'zur, Nice, France; ELSAN, Clinique Saint Michel, Centre de Chirurgie de l'Ob\u00e9sit\u00e9 (CCO), Toulon, France; Adipocible Research Study Group University of Nice C\u00f4te d'Azur and Initiative d'Excellence \u2010 Idex  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Brouchet","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department H\u00f4pital Larrey, CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Benoit","family":"Pag\u00e8s","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department CHU Dijon, 1 BD Mar\u00e9chal de Lattre de Tassigny  Dijon 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H\u00f4pital Larrey, CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-1037","authenticated-orcid":false,"given":"Marco","family":"Alifano","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department Cochin Hospital, University of Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2022.02.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2024.02.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.05.026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.07.021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106914"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061854"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1056795"},{"issue":"7","key":"e_1_2_9_9_1","first-page":"10633","article-title":"Association Between Serum C\u2010Reactive Protein Value and Prognosis of Patients With Non\u2010Small Cell Lung Cancer: A Meta\u2010Analysis","volume":"8","author":"Jing 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