{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:31:05Z","timestamp":1792323065335,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is characterised by a decline in the skeletal muscle mass with increasing age. This poses many challenges to the health and independence of older individuals. New and emerging studies have focused on supplementing leucine\u2010enriched whey protein and resistance training in older adults to mitigate the effects of sarcopenia, including significant muscle mass loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study aimed to comprehensively analyse the current literature regarding the beneficial effects of leucine\u2010enriched whey protein supplementation in older adults. This article systematically reviewed randomised controlled trials, longitudinal studies, and meta\u2010analyses published between 2011 and 2024. The biochemical mechanisms underlying the anabolic properties of leucine, including its role in protein synthesis and mTOR signalling pathways, were explored to elucidate its potential to enhance muscle protein accretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Findings from the reviewed studies indicate that the combined intervention of leucine\u2010enriched whey protein supplementation and resistance training elicits favourable outcomes regarding increased lean muscle mass, muscle strength and physical performance in older adults with sarcopenia. The potential of leucine\u2010enriched whey protein to mitigate muscle protein breakdown is discussed along with its potential synergistic effects with resistance exercise to optimise muscle adaptation. Future research directions, including investigations of optimal dosing regimens, long\u2010term sustainability and potential contraindications, are proposed to enhance the precision and applicability of this intervention strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Leucine\u2010enriched whey protein supplementation combined with resistance training is beneficial in addressing sarcopenia in older adults. This review consolidates the current understanding of this intervention, highlights its potential benefits and provides insights for future research and clinical applications in geriatric muscle health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70060","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T08:52:17Z","timestamp":1757667137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enhancing Muscle Quality: Exploring Leucine and Whey Protein in Sarcopenic Individuals"],"prefix":"10.1002","volume":"16","author":[{"given":"Aiman","family":"Ijaz","sequence":"first","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences The University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma\u00a0Bader\u00a0Ul","family":"Ain","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences The University of Lahore  Lahore Pakistan"},{"name":"School of Food Science and Engineering Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabussam","family":"Tufail","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences The University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raima","family":"Mariam","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences The University of Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Noreen","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences The University of Lahore  Lahore 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