{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:36:42Z","timestamp":1778956602688,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Body composition alterations such as skeletal muscle (SM) loss in cancer patients are associated with poor survival. In turn, immune cell\u2010driven pathways have been linked to muscle wasting. We aimed to investigate the relationship between body composition, tumour\u2010infiltrating lymphocytes and survival in patients with advanced lung cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied 200 patients with advanced lung cancer receiving immunotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200981) or non\u2010immunotherapy regimens (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009119). Body composition including SM index (SMI) at baseline and longitudinal changes were assessed using computed tomography (CT) scans at the third lumbar vertebra. Associations between body composition parameters and overall survival (OS) were evaluated using Cox regression analysis. The median value of SMI, stratified by sex, was used as the cut\u2010off to define groups with high and low baseline SMI. Stable SMI was defined by any increase or &lt;\u20092% decrease per 100\u2009days; loss of SMI was defined by \u2265\u20092% decrease per 100\u2009days. Logistic regression analysis was applied to investigate the association between SMI and peripheral circulating immune cells. Tumour\u2010infiltrating lymphocytes were identified by immunohistochemistry, and their relationship with SMI was evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SMI loss was associated with shorter OS (whole cohort: HR\u2009=\u20092.314, 95% CI\u2009=\u20091.388\u20133.858,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; immunotherapy cohort: HR\u2009=\u20093.028, 95% CI\u2009=\u20091.113\u20138.236,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03; non\u2010immunotherapy cohort: HR\u2009=\u20092.298, 95% CI\u2009=\u20091.191\u20134.435,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). Low baseline SMI was associated with higher CD3\n                      <jats:sup>+<\/jats:sup>\n                      T cell abundance (OR\u2009=\u20091.240, 95% CI\u2009=\u20091.080\u20131.424,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) but lower CD3\n                      <jats:sup>+<\/jats:sup>\n                      CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell abundance (OR\u2009=\u20090.862, 95% CI\u2009=\u20090.762\u20130.974,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) in peripheral blood. Subsequent SMI loss during treatment was also significantly associated with higher CD3\n                      <jats:sup>+<\/jats:sup>\n                      T cell counts (OR\u2009=\u20093.414, 95% CI\u2009=\u20091.301\u20138.961,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) and lower CD3\n                      <jats:sup>+<\/jats:sup>\n                      CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell abundance (OR\u2009=\u20090.666, 95% CI\u2009=\u20090.459\u20130.968,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). Patients with stable SMI had a higher number of CD8\n                      <jats:sup>+<\/jats:sup>\n                      tumour\u2010infiltrating lymphocytes than patients with SMI loss (15.4% vs. 7.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SM loss is an independent predictor for survival in patients with advanced lung cancer and is associated with reduced peripheral and tumour\u2010infiltrating cytotoxic T cell abundance. An inadequate antitumour immune response may contribute to metabolic tissue wasting in cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70063","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T04:34:29Z","timestamp":1757565269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Loss of Skeletal Muscle Mass Is Associated With Reduced Cytotoxic T Cell Abundance and Poor Survival in Advanced Lung Cancer"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7120-2804","authenticated-orcid":false,"given":"Xin","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David\u00a0P.\u00a0J.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Institute for Cancer Research Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Brecheisen","sequence":"additional","affiliation":[{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pathology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven\u00a0M.\u00a0W.","family":"Olde\u00a0Damink","sequence":"additional","affiliation":[{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"},{"name":"Department of General, Visceral, Vascular and Transplantation Surgery University Hospital Essen, Duisberg\u2010Essen University  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander\u00a0S.","family":"Rensen","sequence":"additional","affiliation":[{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a037895"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00854-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01497"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2022.09.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01522-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087577"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01605"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.71714"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13216"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2022.2088814"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023363"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.726257"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.e14061"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27282"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.900823"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.e24080"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.3_suppl.56"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03901-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00565-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13205"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S435366"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12424"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-019-0209-y"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2019.04.007"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjr\/tqae191"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1139\/H08-075"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12107"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-018-0600-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09443-1"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74765-8"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01833-4"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-023-13569-2"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-023-03170-2"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05013-y"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12570"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303486"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00624-w"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0488-6"}],"container-title":["Journal 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