{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:11:23Z","timestamp":1791000683473,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n Cient\u00edfica Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019478","name":"Florida Polytechnic University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["T39_23R group"],"award-info":[{"award-number":["T39_23R group"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Centenarians comprise an age group characterized by exceptional longevity and low age\u2010associated pathologies. However, they still experience physiological decline, and different studies have linked frailty to this population. Exercise interventions reverse frailty and improve functional capacity, but no studies have addressed the effect of an intervention in centenarians. In this study, we assessed the impact of a 12\u2010week resistance exercise intervention in a group of centenarians and characterized their functional capacity as well as the expression of several molecular biomarkers associated with frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 19 centenarians were enrolled, but 7 of them did not complete the study. The remaining 12 centenarians were randomly assigned to the control or intervention group, which was a 12\u2010week resistance exercise intervention. Molecular biomarkers were measured by qRT\u2010PCR and ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The intervention group improved their functional capacity measured by Short Physical Performance Battery (SPPB) (post 5.0 vs 2.3 in pre) and Physical Performance and Mobility Examination (PPME) (6.5 vs 3.8), as well as in frailty status studied by Fried Frailty Phenotype (3.0 vs 3.8) and Frailty Trait Scale 5 (FTS5) (post 30.7 vs 34.0 in pre) scales. ANCOVA revealed that the resistance training led to significant improvements in functional capacity scales SPPB (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and PPME (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as well as Fried Frailty Phenotype (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and FTS5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05). Biomarkers related to frailty\n                      <jats:italic>(EGR1<\/jats:italic>\n                      ,\n                      <jats:italic>miR194\u20105p, miR125b\u20105p<\/jats:italic>\n                      and\n                      <jats:italic>miR454\u20103p)<\/jats:italic>\n                      and inflammation (\n                      <jats:italic>IL\u2010<\/jats:italic>\n                      6 and\n                      <jats:italic>IL\u20101\u03b2)<\/jats:italic>\n                      showed different expression patterns in centenarians (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919) compared to both old (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944, average of 79\u2009years old) and young adults (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934, average of 29\u2009years old) groups. Notably, the intervention was associated with improvements in frailty and inflammation biomarkers expression. Finally, correlation analyses showed significant associations between all functional and frailty variables, with SPPB correlating with\n                      <jats:italic>miR454\u20103p (\u03c1\u2009=\u20090.73)<\/jats:italic>\n                      and FTS5 correlating with\n                      <jats:italic>miR454\u20103p (\u03c1\u2009=\u2009\u22120.83), IL\u20106 (\u03c1\u2009=\u20090.60)<\/jats:italic>\n                      and\n                      <jats:italic>miR125b\u20105p (\u03c1\u2009=\u2009\u22120.55)<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results revealed that resistance exercise intervention enhances functional status and reduces frailty in centenarians, and this is associated with improvements in frailty and inflammation biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70079","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:41:47Z","timestamp":1759401707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Resistance Exercise Intervention Restores Functional Capacity and Improves Frailty Biomarkers in Centenarians"],"prefix":"10.1002","volume":"16","author":[{"given":"Diego","family":"Marcos\u2010Perez","sequence":"first","affiliation":[{"name":"Cellular Oncology Group, Biodonostia (Biogipuzkoa) Health Research Institute  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Hernandez\u2010Vicente","sequence":"additional","affiliation":[{"name":"Growth, Exercise, Nutrition and Development (GENUD) Research Group University of Zaragoza  Zaragoza Spain"},{"name":"Faculty of Health and Sport Science University of Zaragoza  Huesca Spain"},{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Ejercicio F\u00edsico y Salud en Poblaciones Especiales (EXERNET)  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cruces\u2010Salguero","sequence":"additional","affiliation":[{"name":"Cellular Oncology Group, Biodonostia (Biogipuzkoa) Health Research Institute  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Landa","sequence":"additional","affiliation":[{"name":"Cellular Oncology Group, Biodonostia (Biogipuzkoa) Health Research Institute  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Bonvini","sequence":"additional","affiliation":[{"name":"Cellular Oncology Group, Biodonostia (Biogipuzkoa) Health Research Institute  San Sebasti\u00e1n 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of Cachexia, Sarcopenia and 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