{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:03:05Z","timestamp":1790128985151,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372432"],"award-info":[{"award-number":["82372432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072473"],"award-info":[{"award-number":["82072473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305372"],"award-info":[{"award-number":["82305372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302737"],"award-info":[{"award-number":["82302737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012459"],"award-info":[{"award-number":["2022A1515012459"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012689"],"award-info":[{"award-number":["2023A1515012689"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia and intervertebral disc degeneration (IDD) are both highly prevalent among the elderly and have a substantial impact on their quality of life. However, the association between sarcopenia and IDD remains unclear. This study aimed to investigate whether sarcopenia is independently associated with an increased risk of IDD in middle\u2010aged and older adults, using prospective data from the UK Biobank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 378\u2009773 participants from the UK Biobank were included and categorized into three groups based on the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria: normal, probable sarcopenia and confirmed sarcopenia. The association between sarcopenia and IDD was examined using Kaplan\u2013Meier survival analysis and Cox proportional hazards models. Sensitivity analyses included subgroup analyses to assess the robustness of findings and interaction tests to explore potential effect modifiers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of participants was 59\u2009years, with females accounting for 54.8% of the cohort. Over a median follow\u2010up duration of 171\u2009months, 10\u2009585 participants developed IDD. In unadjusted Cox regression analyses, compared to the normal group, the hazard ratios (HRs) for IDD were 1.51 (95% CI: 1.41\u20131.61) in the probable sarcopenia group and 1.47 (95% CI: 1.14\u20131.90) in the confirmed sarcopenia group. After adjusting for multiple covariates, the corresponding HRs were 1.35 (95% CI: 1.26\u20131.44) and 1.41 (95% CI: 1.10\u20131.80), respectively. These associations remained consistent across subgroup analyses. Notably, in BMI\u2010stratified analyses, individuals with sarcopenia and a BMI\u2009&gt;\u200925 had a higher risk of IDD (HR: 1.88; 95% CI: 1.31\u20132.71) compared to those with BMI\u2009\u2264\u200925 (HR: 1.51; 95% CI: 1.06\u20132.16), with a significant interaction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarcopenia is associated with an increased risk of IDD, particularly in overweight or obese individuals. Regular assessment of muscle strength and mass, along with promoting physical activity and adequate nutritional interventions in ageing populations, may help prevent sarcopenia and delay the onset of IDD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70086","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:27:53Z","timestamp":1760448473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Sarcopenia and the Long\u2010Term Risk of Intervertebral Disc Degeneration"],"prefix":"10.1002","volume":"16","author":[{"given":"Jianan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedics Sun Yat\u2010Sen Memorial Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongzhou","family":"Liang","sequence":"additional","affiliation":[{"name":"The Brain Cognition and Brain Disease 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Sun Yat\u2010Sen Memorial Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sun Yat\u2010Sen Memorial Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junquan","family":"Liang","sequence":"additional","affiliation":[{"name":"Shenzhen Bao'an Chinese Medicine Hospital, The Seventh Clinical Medical School of Guangzhou University of Chinese Medicine  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sun Yat\u2010Sen Memorial Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sun Yat\u2010Sen Memorial Hospital  Guangzhou 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