{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T20:03:12Z","timestamp":1763928192347,"version":"3.45.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000212050"],"award-info":[{"award-number":["RS\u20102023\u201000212050"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While obesity confers a survival advantage, weight loss adversely affects the survival of patients undergoing haemodialysis. However, given the limited information regarding its long\u2010term effects on mortality and cardiovascular events, the health benefits of weight gain remain uncertain, particularly in Asian patients undergoing haemodialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a prospective multicentre cohort of patients undergoing haemodialysis in South Korea, patients whose dry weight was recorded at baseline and after 1\u2009year were analysed. Patients were stratified into five groups according to annual dry weight change: stable (\u22122.0% to 1.9%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009245), mild (2.0% to 6.9%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200992) and moderate (\u2265\u20097.0%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) dry weight gain and mild (\u22125.0% to \u22122.1%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200991) and moderate (&lt;\u2009\u22125.0%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200977) dry weight loss. The associations of annual dry weight change with physical function and health\u2010related quality of life were examined using cross\u2010sectional analysis. The impact of annual dry weight changes on all\u2010cause mortality and a composite of major adverse cardiovascular events (MACEs), defined as myocardial infarction, unstable angina, ischaemic stroke and peripheral artery disease requiring revascularization, was assessed in a longitudinal cohort of 525 individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In cross\u2010sectional analysis, patients with diminished physical ability had a higher frequency of dry weight fluctuations. In longitudinal analysis, the mean age of the study participants was 59.9\u2009years, and 62.3% were men. During a median follow\u2010up of 3.1\u2009years, death and MACE occurred in 105 (20.0%) and 31 (5.9%) patients, respectively. The risk of all\u2010cause mortality was higher in patients with moderate dry weight gain or loss than in those with stable dry weight (adjusted hazard ratio [aHR] for moderate weight gain, 2.22; 95% confidence interval [CI], 0.96\n                      <jats:bold>\u2013<\/jats:bold>\n                      5.13;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06; and aHR for moderate weight loss, 1.78; 95% CI, 1.07\n                      <jats:bold>\u2013<\/jats:bold>\n                      2.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). The risk of MACE was significantly higher in patients with weight gain (including mild and moderate) than in those with a stable dry weight (aHR, 3.02; 95% CI, 1.32\n                      <jats:bold>\u2013<\/jats:bold>\n                      6.88;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Specifically, the increased risk of all\u2010cause mortality attributable to moderate dry weight gain was limited to patients with obesity, whereas that for moderate dry weight loss was limited to patients with a normal body mass index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate weight gain and loss were differentially associated with lower survival among patients undergoing haemodialysis, with the former in patients with obesity and the latter in normal\u2010weight patients. Particularly, dry weight gain increased the risk of cardiovascular events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70100","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:23:49Z","timestamp":1760448229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis"],"prefix":"10.1002","volume":"16","author":[{"given":"Yoosun","family":"Joo","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Kyung Hee University Hospital at Gangdong  Seoul Republic of Korea"},{"name":"Department of Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihoon","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Kyung Hee University Hospital at Gangdong  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang\u2010Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Kyung Hee University Hospital at Gangdong  Seoul Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, College of Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Kyung Hee University Hospital at Gangdong  Seoul Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, College of Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Young","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Kyung Hee University Hospital at Gangdong  Seoul Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, College of Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, College of Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital Kyung Hee University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon\u00a0Seok","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, College of Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital Kyung Hee University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine CHA University Bundang Medical Center  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine VHS Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang\u00a0Jee","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Korea University 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