{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:55:22Z","timestamp":1791896122334,"version":"4.3.4"},"reference-count":119,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Resistance training (RT) is the first\u2010line treatment to improve sarcopenia features. However, increasing muscle mass with RT remains challenging and displays inconsistent results. Manipulating training variables may present a novel approach to improve muscle mass gain in sarcopenic individuals. The present study aimed to measure the effectiveness of RT alone on muscle mass outcomes in older adults with sarcopenia and determine the influence of RT variables on muscle mass improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review according to PRISMA standards to gather studies that conducted a supervised RT without nutritional intervention in sarcopenia\u2010diagnosed older adults with a muscle mass outcome versus a control group. A search strategy was performed on PubMed, Medline, Cochrane and Google Scholar in the last 14\u2009years, from the publication of the first agreement on the diagnosis (EWGSOP, 2010). Along with sample characteristics, we extracted and analysed the following training variables: frequency (number of sessions per week), intensity (in rating perceived effort and in % of the one repetition maximal load), duration (weeks), volume (number of sets per week), periodization (yes\/no) and muscle failure (yes\/no). First, we standardized the outcome with Hedge's\n                      <jats:italic>g<\/jats:italic>\n                      and pooled the effect size (ES) of each study in a univariate meta\u2010analysis adjusted for risk of bias. Then, we performed training composition comparisons between \u2018effective interventions\u2019 and \u2018ineffective interventions\u2019, which were previously classified based on the 95% confidence interval (CI) effect size. Finally, relevant variables were regressed as moderators of the weighted ES in a mixed\u2010effects model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 14 studies representing 528 individuals (73.1\u2009\u00b1\u20096.6\u2009years, 385 women [73%] and 143 men [27%]) were included for analysis. A significant effect of RT to improve muscle mass was found with a small weighted ES estimate (\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u20090.38 [0.18; 0.58] 95% CI,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001). There was no publication bias across studies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.7). \u2018Ineffective interventions\u2019 included significantly older individuals (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.01). Training composition was homogenous between the groups. The final model showed that age was the only significant moderator of the ES (estimate\u2009=\u2009\u22120.06 [\u22120.08; \u22120.03] 95% CI,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In sarcopenic older adults, designing an evidence\u2010based RT induces significant gains in muscle mass, but training variables manipulation does not yield greater outcomes. This study also unveils that ageing with sarcopenia negatively affects the significant improvement of muscle mass induced by RT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70162","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T23:40:27Z","timestamp":1765323627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of Resistance Training Variables to Improve Muscle Mass Outcomes in Sarcopenia: A Systematic Review With Meta\u2010Regressions"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-9356","authenticated-orcid":false,"given":"Leo","family":"Delaire","sequence":"first","affiliation":[{"name":"Aging Medicine Department H\u00f4pital Lyon Sud, Hospices Civils de Lyon  Oullins\u2010Pierre B\u00e9nite France"},{"name":"CarMeN Laboratory, Inserm U1060, Inrae 1397, Universit\u00e9 Claude Bernard Lyon 1  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