{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:34:19Z","timestamp":1789770859637,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374554"],"award-info":[{"award-number":["82374554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The purpose of this study was to explore the associations of the triglyceride\u2010glucose (TyG) index and its clinically relevant derivatives with handgrip strength asymmetry (HGS\u2010A) in a nationally representative cohort of older adults in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we used the data of participants aged between 45 and 80\u2009years who were from wave 2015 of the China Health and Retirement Longitudinal Study (CHARLS). HGS asymmetry was defined as the ratio of nondominant to dominant HGS, categorized into the following four groups: 0.9\u20131.1 (nonasymmetry), 0.80\u2009\u2264\u2009ratio &lt;\u20090.90 or 1.10\u2009&lt;\u2009ratio \u2264\u20091.20 (mild asymmetry), 0.70\u2009\u2264\u2009ratio &lt;\u20090.80 or 1.20\u2009&lt;\u2009ratio \u2264\u20091.30 (moderate asymmetry) and ratio &lt;\u20090.70 or ratio &gt;\u20091.30 (severe asymmetry). Multivariable logistic regression was adopted to assess the association of TyG, TyG\u2010body mass index (TyG\u2010BMI) and TyG\u2010waist\u2010to\u2010height ratio (TyG\u2010WHtR) with HGS asymmetry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3521 middle\u2010aged and elderly individuals (mean age: 59.74\u2009years; 47.9% male) were included, with the mean TyG of 8.733\u2009\u00b1\u20090.660, mean TyG\u2010BMI of 243.559\u2009\u00b1\u200931.120, mean TyG\u2010WHtR of 4.702\u2009\u00b1\u20090.733. The mean HGS ratio was 0.97\u2009\u00b1\u20090.16, and participants were classified into the following four groups: nonasymmetry (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092174), mild asymmetry (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009972), moderate asymmetry (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009237) and severe asymmetry (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009138). Overall, the prevalence of HGS asymmetry was 38.26%. The prevalence of severe asymmetry increased across TyG quartiles from 3.7% to 4.5% (Q1\u2013Q4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). TyG\u2010WHtR showed increasing prevalence of severe asymmetry from 4.9% to 5.1% across quartiles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042). For TyG\u2010BMI, it exhibited an inverse relationship with severe asymmetry prevalence decreasing from 5.3% to 2.4%. Multivariable\u2010adjusted models confirmed that TyG\u2010WHtR demonstrated the strongest effect size with Q2 and Q3 associated with significantly increased odds of asymmetry (OR\u2009=\u20091.507 and 1.437, respectively). TyG\u2010BMI showed a protective effect with higher quartiles associated with reduced odds (Q2\u2013Q4 OR range: 0.973\u20130.984).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher levels of TyG\u2010WHtR and lower levels of TyG\u2010BMI are both associated with a higher prevalence and severity of HGS asymmetry in middle\u2010aged and older Chinese adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70165","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:01:31Z","timestamp":1770008491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Triglyceride\u2010Glucose Index and Its Related Parameters With Handgrip Strength Asymmetry"],"prefix":"10.1002","volume":"17","author":[{"given":"Yuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Endocrine and Metabolic Disease Medical Center Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"},{"name":"Branch of National Clinical Research Centre for Metabolic Diseases  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-330X","authenticated-orcid":false,"given":"Yali","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Endocrine and Metabolic Disease Medical Center Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"},{"name":"Branch of National Clinical Research Centre for Metabolic Diseases  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.04.041"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16050740"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2024.101271"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31786-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12933"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2024.105385"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.04.030"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2024.08.026"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00208"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R087510"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.325532"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12643"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2023-0557"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-022-01456-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117242"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2010.00610.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0945"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01414-4"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80305-1"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03337729"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207308"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02819-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16930"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010023\u201002539\u2010z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs115"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.04.015"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S410834"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/78693"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.03.029"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.283549"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2343-x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12898"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88880"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103519"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315896"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12901"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15010020"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.22.010402.102912"}],"container-title":["Journal of Cachexia, Sarcopenia and 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