{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:15:04Z","timestamp":1793931304415,"version":"4.8.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Irisin, an exercise\u2010induced myokine and adiponectin, an adipocyte\u2010derived hormone, are involved in energy metabolism and musculoskeletal health. However, their associations with obesity, abdominal obesity, sarcopenia and sarcopenic obesity remain unclear, and longitudinal evidence is limited. This study investigated the cross\u2010sectional and longitudinal associations of these biomarkers with obesity\u2010 and sarcopenia\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used data from the Hallym Aging Study, a cohort of Korean adults aged \u2265\u200945\u2009years (45\u201364\u2009years: 30%, \u226565\u2009years: 70%). The cross\u2010sectional analysis used the third wave (2010), while the longitudinal analysis included the second (2007, baseline) and third waves. In both analyses, sex\u2010specific tertile groups (T1, T2 and T3) were defined based on baseline levels and changes in irisin and adiponectin over 3\u2009years. Lean soft tissue and fat mass were assessed using dual\u2010energy x\u2010ray absorptiometry. Obesity was defined as body fat percentages &gt;\u200929.7% for males and &gt;\u200937.2% for females. For individuals without obesity, low ALST was defined as appendicular lean soft tissue (ALST)\/height\n                      <jats:sup>2<\/jats:sup>\n                      \u2009&lt;\u20097.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      for males and &lt;\u20095.4\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      for females. For individuals with obesity, low ALST was defined as an ALST\/body weight &lt;\u200926.8% for males and &lt;\u200921.0% for females. Multivariable logistic regression was performed to examine the associations between circulating irisin and adiponectin and obesity\u2010 and sarcopenia\u2010related outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 357 and 360 participants were included in the cross\u2010sectional analyses of irisin and adiponectin, respectively, and 351 were included in the longitudinal analysis (baseline 2007; median age: 70\u2009years; 54% female). In cross\u2010sectional analysis, irisin was not significantly associated with obesity\u2010 and sarcopenia\u2010related outcomes after adjustment for confounding variables. Longitudinally, the greatest irisin increase group (T3) over 3\u2009years had higher odds of obesity [odds ratio (OR) 2.39, 95% confidence interval (CI) 1.24\u20134.71], abdominal obesity (OR 2.19, 95% CI 1.04\u20134.72), sarcopenia (OR 2.11, 95% CI 1.14\u20133.97), sarcopenic obesity (OR 3.40, 95% CI 1.43\u20138.61) and low ALST (OR 2.21, 95% CI 1.24\u20133.99) at the follow\u2010up than the T1 group. In contrast, adiponectin levels showed inverse associations with obesity (OR 0.47, 95% CI 0.24\u20130.93) and abdominal obesity (OR 0.48, 95% CI 0.25\u20130.90) only in cross\u2010sectional analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite irisin's proposed protective role against obesity and sarcopenia, our findings suggest that greater 3\u2010year increases in irisin were associated with increased odds of obesity, abdominal obesity, sarcopenia and sarcopenic obesity at the follow\u2010up. Conversely, adiponectin showed an inverse cross\u2010sectional association with obesity and abdominal obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70172","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:16:33Z","timestamp":1766999793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cross\u2010Sectional and Longitudinal Associations of Irisin and Adiponectin With Obesity, Sarcopenia and Sarcopenic Obesity"],"prefix":"10.1002","volume":"17","author":[{"given":"Yejin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, College of Medicine Hallym University  Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u00a0Ji","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Hallym University Sacred Heart Hospital, College of Medicine Hallym University  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine, Hallym University College of Medicine  Chuncheon South Korea"},{"name":"Hallym Research Institute of Clinical Epidemiology, Hallym University College of Medicine  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Young","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine, Hallym University College of Medicine  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u00a0Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Hallym University Sacred Heart Hospital, College of Medicine Hallym University  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u00a0Soon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chuncheon Sacred Heart Hospital, College of Medicine Hallym University  Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jwa\u2010Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine &amp; Kidney Research Institute, Hallym University Sacred Heart Hospital, College of Medicine Hallym University  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-1613","authenticated-orcid":false,"given":"Hye\u2010Mi","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Hallym University Sacred Heart Hospital, College of Medicine Hallym University  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"United Nations.World Population Ageing 2019 Report. 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