{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:57:03Z","timestamp":1790438223256,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201023\u2010IAHU\u20100011"],"award-info":[{"award-number":["ANR\u201023\u2010IAHU\u20100011"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["MP0022856"],"award-info":[{"award-number":["MP0022856"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frailty is a prevalent syndrome in older adults and is associated with increased vulnerability to adverse health outcomes. Growth differentiation factor 15 (GDF\u201015), a cytokine involved in mitochondrial dysfunction and inflammation, has been proposed as a potential biomarker for age\u2010related conditions. Evidence on the association between GDF\u201015 and frailty in older adults is limited. This study explores the relationship between plasma GDF\u201015 levels and frailty onset in community\u2010dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A secondary analysis was performed on 1096 participants (mean age\u2009=\u200975.2\u2009\u00b1\u20094.5\u2009years; 64.5% women) from the Multidomain Alzheimer Prevention Trial (MAPT). Plasma GDF\u201015 levels were measured at year 1. Frailty was assessed using the Fried phenotype. Logistic regression was used to examine cross\u2010sectional associations between GDF\u201015 and frailty, while mixed effects logistic regression or Cox proportional hazards models assessed longitudinal associations over a 4\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher plasma GDF\u201015 levels (both as continuous and categorical) were cross\u2010sectionally associated with frailty (high vs. low GDF\u201015: OR\u2009=\u20093.56, 95% CI\u2009=\u20091.58\u20138.03). Longitudinally, very high GDF\u201015 levels predicted an increased risk of incident frailty (HR\u2009=\u20091.69, 95% CI\u2009=\u20091.03\u20132.78).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated plasma GDF\u201015 levels were associated with frailty in older adults, suggesting its potential as a biomarker for increased vulnerability and an indicator of increased risk over time. Our results support a pleiotropic role of GDF\u201015, with low physiological levels not contributing to frailty development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70182","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:48:46Z","timestamp":1768978126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations Between Growth Differentiating Factor\u201015 and Frailty in Older Adults From the MAPT Study"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-6015","authenticated-orcid":false,"given":"Juan\u00a0Luis","family":"S\u00e1nchez\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse, Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse, Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295 University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lucas","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMR 1297 Institute of Metabolic and Cardiovascular Diseases  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"CERPOP UMR 1295 University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse, Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295 University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipe","family":"de Souto\u00a0Barreto","sequence":"additional","affiliation":[{"name":"IHU HealthAge  Toulouse France"},{"name":"Institut du Vieillissement, G\u00e9rontop\u00f4le de Toulouse, Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"CERPOP UMR 1295 University of Toulouse III, Inserm, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the MAPT\/DSA 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Webber S.Patel J. R.Kizer et\u00a0al. 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