{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:13:20Z","timestamp":1792750400190,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201553"],"award-info":[{"award-number":["82201553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Iterative decomposition of water and fat with echo asymmetry and least\u2010squares estimation quantitation (IDEAL\u2010IQ), a quantitative 6\u2010point Dixon magnetic resonance imaging (MRI) sequence, has been increasingly used for quantifying muscle fat fraction (FF) in neuromuscular disorders. However, its utility for correlating FF with disease severity and mapping spatiotemporal disease progression in Duchenne muscular dystrophy (DMD) requires further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 10 patients with dystrophinopathies (seven DMD and three BMD) we correlated the muscle FF with the histopathological fatty infiltration. IDEAL\u2010IQ MRI images of 19 individual lower limb muscles were acquired from 133 DMD patients and 41 healthy controls. Ambulatory function tests, including three timed function tests (TFTs) and North Star Ambulatory Assessment (NSAA), were performed. We investigated the spatial distribution of fatty infiltration across five axial MRI slices. Disease progression patterns were analysed using a piecewise linear model and a normal cumulative distribution function model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant positive correlation between muscle FF on MRI and histopathologic fatty infiltration was observed (\u03c1\u2009=\u20090.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A mild to moderate correlation was noted for the FF of 19 individual muscles, excluding the sartorius and gracilis muscles, with TFTs (\u03c1\u2009=\u20090.27\u20130.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and NSAA (\u03c1\u2009=\u2009\u22120.32\u2013\u22120.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). All the eight individual muscles, except the tibialis posterior muscle, showed an inhomogeneous fatty infiltration pattern with higher FF in muscle ends compared to bellies. Thigh muscle FF aligned well with both piecewise linear and sigmoidal models, showing non\u2010linear increases with disease duration. The piecewise linear model identified an average inflection point for thigh muscle FF at 7.3 (range, 5.2\u20137.6) years, with average annual FF increase of 1.7% before and 6.7% after the point in DMD. The average \u03bc of DMD patients for thigh muscles was 11.4\u2009years (\u00b12.8), occurring 7.6\u2009years earlier compared to BMD patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study demonstrates a significant relationship between muscle FF on IDEAL\u2010IQ MRI and histopathologic muscle fatty infiltration, as well as ambulatory clinical function in DMD. DMD patients exhibit a distinct and inhomogeneous fat infiltration pattern of lower limb muscles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70205","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:29:02Z","timestamp":1769412542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantitative MRI Findings and Their Relationship to Muscle Histopathology and Ambulatory Clinical Function in Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"17","author":[{"given":"Yanyu","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Neurology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology the First Affiliated Hospital of University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University First Hospital  Beijing 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