{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:15:42Z","timestamp":1788344142497,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Duchenne muscular dystrophy (DMD) is an X\u2010linked recessive disorder that affects dystrophin production, characterized by progressive neuromuscular dysfunction, often accompanied by osteoporosis. We prospectively evaluate the effects of bisphosphonates on bone micro\u2010architecture reflected by trabecular bone score (TBS) of patients with DMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 72 male children or adolescents with DMD were included, with a mean age of 9.5\u2009\u00b1\u20091.8\u2009years. They were divided into bisphosphonate treatment groups and control group based on areal bone mineral density (aBMD) and history of fragility fractures. Patients in bisphosphonate treatment groups randomly received intravenous infusion of 5\u2009mg zoledronic acid (ZOL) annually or oral 70\u2009mg alendronate weekly for three years. All patients took calcium 600\u2009mg plus 125\u2009IU vitamin D daily and calcitriol 0.25\u2009\u03bcg every other day. TBS at the lumbar spine (LS) and aBMD at the LS, femoral neck (FN) and total hip (TH) were measured annually by dual\u2010energy X\u2010ray absorptiometry. Serum levels of \u03b2\u2010isomerized carboxy\u2010telopeptide of type I collagen and alkaline phosphatase were measured annually during the follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 25 (86.2%), 26 (92.9%) and 13 (86.7%) patients in the ZOL, alendronate and control groups completed the study. After 3\u2009years, TBS Z\u2010score increased from baseline by 1.13 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), 0.68 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and 0.26 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) in the ZOL, alendronate and control groups, respectively. The mean increase in TBS Z\u2010score from baseline was significantly greater in both bisphosphonate treatment groups compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No significant difference was found between the ZOL and alendronate groups. LS, FN and TH aBMD increased by 35.8%, 23.7% and 34.5% in the ZOL group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 vs. baseline and control group) and by 21.5%, 29.3% and 25.0% in the alendronate group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 vs. baseline and control group). LS and FN aBMD Z\u2010scores increased by 1.56 and 1.63 in the ZOL group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 vs. baseline), by 1.32 and 1.48 in the alendronate group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 vs. baseline). Bisphosphonates demonstrated a favourable safety profile during the study period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This relatively long\u2010term study confirms that zoledronic acid and alendronate are beneficial to improve micro\u2010architecture reflected by TBS and aBMD of children or adolescents with DMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70227","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:17:41Z","timestamp":1772968661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Bisphosphonates on Bone Micro\u2010Architecture of Children With Duchenne Muscular Dystrophy: A Prospective Comparative Study"],"prefix":"10.1002","volume":"17","author":[{"given":"Songqi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-4902","authenticated-orcid":false,"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology Peking Union Medical College 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