{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:16:03Z","timestamp":1784546163534,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272926"],"award-info":[{"award-number":["82272926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is a prognostic factor in patients with early\u2010stage non\u2010small cell lung cancer (NSCLC). Previous studies have focused on muscle loss, yet comprehensive body composition (BC) alterations in this population remain poorly characterized. This study aimed to delineate BC alterations using bioelectrical impedance analysis (BIA) in early\u2010stage NSCLC patients with preoperative sarcopenia, with a specific focus on sex\u2010specific disparities and the identification of independent BC factors associated with sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case\u2010control study, 460 patients with Stage I\u2013II NSCLC were initially enrolled from two tertiary hospitals in Anhui, China. Sarcopenia was diagnosed preoperatively based on Asian Working Group for Sarcopenia 2019 criteria. Multifrequency BIA was performed within 48\u2009h before surgery. Propensity score matching (PSM) at a 1:4 ratio was applied to balance covariates (age, sex, height, physical activity, nutritional status, clinical stage, histology, extent of resection and diabetes). Multivariable logistic regressions were used to examine the associations between BC parameters and sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, 47 sarcopenic and 162 nonsarcopenic patients were well\u2010matched. Sarcopenic patients exhibited systemic depletion beyond reduced muscle mass, including lower body fat mass (BFM: 12.70 vs. 18.60\u2009kg), body cell mass (BCM: 23.90 vs. 29.10\u2009kg), bone mineral content (BMC: 2.22 vs. 2.52\u2009kg\u2009=\u20090.002), basal metabolic rate (BMR: 1151.00 vs. 1340.50\u2009kcal) and elevated extracellular water\/intracellular water ratio (ECW\/ICW: 0.64 vs. 0.63; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Distinct sex\u2010specific phenotypes were identified: Sarcopenic females demonstrated coordinated reductions in muscle, fat and minerals (appendicular skeletal muscle mass [ASM]: 13.10 vs. 15.43\u2009kg; BFM: 11.20 vs. 19.20\u2009kg; percent body fat [PBF]: 25.41% vs. 32.88%; BMC: 2.05 vs. 2.26\u2009kg; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas males exhibited isolated muscle loss with preserved adiposity and minerals (PBF: 23.04% vs. 24.29%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.463; BMC: 2.64 vs. 2.80\u2009kg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.141). In the fully adjusted model, ASM (OR\u2009=\u20090.03, 95%CI: 0.01\u20130.08), BFM (OR\u2009=\u20090.81, 95%CI: 0.75\u20130.87) and BMR (OR\u2009=\u20090.95, 95%CI: 0.94\u20130.97) were independent factors associated with sarcopenia. Sex significantly modified associations for waist\u2013hip ratio, soft lean mass, FFM and PBF (all\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009&lt;\u20090.05). Sensitivity analyses based on sarcopenia severity supported the robustness of the primary findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative sarcopenia in early\u2010stage NSCLC involves multicompartment depletion accompanied by cellular dysfunction and metabolic impairment, exhibiting distinct sex\u2010specific phenotypes. BIA provides a practical tool for multidimensional BC assessment, necessitating to integrate it into clinical workflows and developing sex\u2010tailored prehabilitation strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70230","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:17:39Z","timestamp":1770967059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Body Composition in Resectable Non\u2010Small Cell Lung Cancer Patients With Preoperative Sarcopenia: A Propensity\u2010Matched Analysis"],"prefix":"10.1002","volume":"17","author":[{"given":"Zhu\u2010zhu","family":"Wang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"School of Nursing Anhui Medical University  Hefei Anhui 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