{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:15:34Z","timestamp":1788344134561,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In uterine cervical cancer (UCC), reduced muscle mass and radiodensity have been linked to unfavourable clinical outcomes. Our aim was to elucidate the associations between body composition (BC) and intratumoural immune cells in patients with UCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, BC was analysed in 61 patients with UCC using staging computed tomography. The parameters of BC were skeletal muscle area (SMA), skeletal muscle radiodensity, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and intramuscular adipose tissue (IMAT). The radiodensities of VAT, SAT and IMAT were also estimated. Tumour specimens underwent histopathological analysis to quantify stromal and intratumoural CD45\u2010positive cells. Associations between body composition parameters and tumour immune cell infiltration were analysed using ANOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with low muscle radiodensity (myosteatosis) had a lower proportion of stromal CD45\u2010positive cells than patients with normal muscle radiodensity (21.6%\u2009\u00b1\u200921.90% vs. 34.85%\u2009\u00b1\u200925.55%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). High levels of SAT were associated with lower scores for tumour\u2010infiltrating CD45 cells (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). High IMAT radiodensity was associated with lower stromal CD45 scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Myosteatosis, high SAT and increased IMAT radiodensity were associated with reduced stromal and intratumoural immune cell infiltration in patients with UCC. These body composition parameters may serve as prognostic markers and should be explored in risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70241","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:22:18Z","timestamp":1773159738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Body Composition and Intratumoural Immune Cells in Patients With Uterine Cervical Cancer"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-3943","authenticated-orcid":false,"given":"Alexey","family":"Surov","sequence":"first","affiliation":[{"name":"Institute of Radiology, Neuroradiology and Nuclear Medicine, Johannes\u2010Wesling\u2010Klinikum Minden, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Katrin","family":"H\u00f6hn","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattes","family":"Hinnerichs","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Jonas","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine University Hospital of Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Borggrefe","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Neuroradiology and Nuclear Medicine, Johannes\u2010Wesling\u2010Klinikum Minden, Ruhr\u2010University Bochum  Bochum 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