{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:03:22Z","timestamp":1792602202647,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2021\u2010SGR\u201000817"],"award-info":[{"award-number":["2021\u2010SGR\u201000817"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012637","name":"University of the East","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Management of sarcopenia by nutritional and lifestyle interventions is a challenge. The aim is to assess the effectiveness of a phenolic\u2010rich extra virgin olive oil (EVOO), alone or combined with a prebiotic (PREB) (fructooligosaccharides and inulin), to improve skeletal muscle mass and function in home\u2010dwelling older adults (60\u201380\u2009years) with at least one sarcopenia parameter altered.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A 12\u2010week randomised, double\u2010blind, parallel, placebo\u2010controlled, three\u2010arm clinical trial was conducted. Intervention groups were as follows: (1) refined olive oil (ROO; 30\u2009mL\/day; 90\u2010mg caffeic acid)\u2009+\u2009maltodextrin placebo (7.5\u2009g\/day); (2) EVOO (30\u2009mL\/day; 296\u2013300\u2010mg caffeic acid)\u2009+\u2009maltodextrin placebo (7.5\u2009g\/day); or (3) EVOO\u2009+\u2009prebiotic (EVOO\u2009+\u2009PREB; 30\u2009mL\/day\u2009+\u20097.5\u2009g\/day). Everyone followed co\u2010created dietary and physical activity recommendations. A 12\u2010week follow\u2010up after intervention cessation was assessed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010eight participants (69.6\u2009\u00b1\u20094.1\u2009years; 31 women) with probable sarcopenia were assigned to ROO (\n n<\/jats:italic>\n \u2009=\u200913), EVOO (\n n<\/jats:italic>\n \u2009=\u200914) or EVOO\u2009+\u2009PREB (\n n<\/jats:italic>\n \u2009=\u200911) intervention groups. At the end\u2010of\u2010intervention, assessed by ultrasound, EVOO\u2009+\u2009PREB compared to EVOO significantly increased muscle thickness of the quadriceps in females, mean (95% CI) (0.230\u2009cm [0.008; 0.45],\n p<\/jats:italic>\n \u2009=\u20090.044), cross\u2010sectional area of the rectus femoris in all populations (0.827\u2009cm\n 2<\/jats:sup>\n [0.16; 1.5],\n p<\/jats:italic>\n \u2009=\u20090.017) and females (0.569\u2009cm\n 2<\/jats:sup>\n [\u22121.0; \u22120.08],\n p<\/jats:italic>\n \u2009=\u20090.024), and rectus femoris muscle thickness in all population (0.195\u2009cm [0.04; 0.35]\n p<\/jats:italic>\n \u2009=\u20090.015) and females (0.179\u2009cm [0.05; 0.31]\n p<\/jats:italic>\n \u2009=\u20090.009). Also, EVOO\u2009+\u2009PREB compared to ROO increased the cross\u2010sectional area of the rectus femoris (0.579\u2009cm\n 2<\/jats:sup>\n [0.07; 1.1],\n p<\/jats:italic>\n \u2009=\u20090.026) and rectus femoris muscle thickness (0.133\u2009cm [0.00; 0.27],\n p<\/jats:italic>\n \u2009=\u20090.050) in females. At 12\u2010week follow\u2010up, EVOO and EVOO\u2009+\u2009PREB, compared to ROO, significantly increased skeletal muscle mass and appendicular skeletal muscle mass in all populations assessed by bioelectrical impedance analysis (BIA). Also, EVOO, compared to ROO, significantly increased skeletal muscle mass index and appendicular skeletal muscle mass index. In addition, at 12\u2010week follow\u2010up, EVOO, compared to ROO, improved the overall quality of life score in females.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Consuming phenolic\u2010rich EVOO, alone or combined with prebiotics, improved muscle mass assessed by ultrasound at the end\u2010of\u2010intervention and by BIA at 12\u2010week follow\u2010up. Further studies are needed to confirm these promising results.<\/jats:p>\n \n Trial Registration:<\/jats:bold>\n Registration number: NCT05485402;\n https:\/\/clinicaltrials.gov\/study\/NCT05485402<\/jats:ext-link>\n ; registration date: 03\/08\/2022.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcsm.70247","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:13:58Z","timestamp":1773026038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Phenolic\u2010Rich Extra Virgin Olive Oil and Prebiotics on Sarcopenia in Older Adults: FOOP\u2010Sarc Project"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-0026","authenticated-orcid":false,"given":"Maria","family":"Besora\u2010Moreno","sequence":"first","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC\u2010Salut) Universitat Rovira i Virgili Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-5795","authenticated-orcid":false,"given":"Claudia","family":"Jim\u00e9nez\u2010ten\u00a0Hoevel","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC\u2010Salut) Universitat Rovira i Virgili Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8948-2215","authenticated-orcid":false,"given":"Judit","family":"Queral","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC\u2010Salut) Universitat Rovira i Virgili Reus 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i Dalt La Vila, Institut Catal\u00e0 de la Salut Badalona Spain"},{"name":"Grup de Recerca ecoAP IDIAP Jordi Gol i Gurina Barcelona Spain"},{"name":"Grup de Treball d'Ecografia en Atenci\u00f3 Prim\u00e0ria (ecoAP) de CAMFiC Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leann","family":"Constance\u00a0Sleebos","sequence":"additional","affiliation":[{"name":"Natura Foundation Numansdorp the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wout","family":"van Helden","sequence":"additional","affiliation":[{"name":"Natura Foundation Numansdorp the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-9531","authenticated-orcid":false,"given":"Elisabet","family":"Llaurad\u00f3","sequence":"additional","affiliation":[{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC\u2010Salut) Universitat 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