{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:39:39Z","timestamp":1791589179247,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/01238"],"award-info":[{"award-number":["PI21\/01238"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI24\/00829"],"award-info":[{"award-number":["PI24\/00829"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI22\/00329"],"award-info":[{"award-number":["FI22\/00329"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Compared to their healthy peers, children and adolescents with type 1 diabetes are at an increased risk of adverse changes in body composition, including increased fat mass along with reductions in lean and bone mass. Although exercise has shown promise in improving body mass index in this population, the individual effects of resistance training on specific body composition parameters remain understudied. The aim of the study was to evaluate the effects of resistance training supported by the mHealth application Diactive\u20101 on body composition in children and adolescents with type 1 diabetes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Sixty\u2010two participants with type 1 diabetes (aged 8\u201318\u2009years old; 48% females) participated in a 24\u2010week randomised controlled trial and were assigned to either the usual care group (\n n<\/jats:italic>\n \u2009=\u200932) or the exercise group (\n n<\/jats:italic>\n \u2009=\u200930). The intervention was delivered via the Diactive\u20101 app, which generates progressive overload resistance training programmes tailored to real\u2010time glycaemia and provides educational support. Body composition was assessed using anthropometry and dual\u2010energy X\u2010ray absorptiometry, with fat, lean and bone measurements standardised by age, sex and ethnicity. Linear mixed models were used to evaluate between\u2010group differences in change over time under both intention\u2010to\u2010treat (ITT) and per\u2010protocol (PP) approaches.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At 24\u2009weeks, in the ITT analysis, the intervention group showed greater gains in lean mass (mean difference [MD]\u2009=\u20090.88\u2009kg; 95% confidence interval [CI] 0.09 to 1.66; Hedges'\n g<\/jats:italic>\n \u2009=\u20090.568) and whole\u2010body bone mineral content less head (MD\u2009=\u200932.40\u2009g; 95% CI 6.90 to 57.89;\n g<\/jats:italic>\n \u2009=\u20090.644) compared with those in the usual care group. No changes were observed in anthropometric measures, fat mass\u2013related regions or standardised variables (\n p<\/jats:italic>\n \u2009>\u20090.05). The risk of probable sarcopenia was lower in the intervention group (relative risk [RR]\u2009=\u20090.17; 95% CI 0.04 to 0.73; Cohen's\n h<\/jats:italic>\n \u2009=\u20090.987) than in the usual care group. Findings were directionally consistent in the PP analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This intervention increased bone\u2010related outcomes and was associated with modest gains in lean mass and a lower risk of probable sarcopenia in youths with type 1 diabetes. These findings highlight the potential of the Diactive\u20101 app as an adjunct tool to support musculoskeletal health in youths with type 1 diabetes.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n identifier: NCT06048757\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcsm.70257","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:09:55Z","timestamp":1773922195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Diactive\u20101\u2013Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes"],"prefix":"10.1002","volume":"17","author":[{"given":"Jacinto","family":"Mu\u00f1oz\u2010Pardeza","sequence":"first","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u00a0Francisco","family":"L\u00f3pez\u2010Gil","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad Esp\u00edritu Santo Samborond\u00f3n Ecuador"},{"name":"Faculty of Health Sciences Universidad Aut\u00f3noma de Chile Temuco Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Hormaz\u00e1bal\u2010Aguayo","sequence":"additional","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA Pamplona Spain"},{"name":"Vicerrector\u00eda de Investigaci\u00f3n y Postgrado Universidad de La Serena La Serena Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA Pamplona Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Agostinis\u2010Sobrinho","sequence":"additional","affiliation":[{"name":"Health Research and Innovation Science Center Klaipeda University Klaip\u0117da Lithuania"},{"name":"Sport Physical Activity and Health Research & Innovation Center Polytechnic Institute of Guarda Guarda Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Ezzatvar","sequence":"additional","affiliation":[{"name":"Lifestyle Factors With Impact on Ageing and Overall Health (LAH) Research Group, Departamento de Enfermer\u00eda Universitat de Val\u00e8ncia Valencia Spain"},{"name":"Vicerrector\u00eda de Investigaci\u00f3n y Postgrado Universidad de Los Lagos Osorno Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1397-7182","authenticated-orcid":false,"given":"Antonio","family":"Garc\u00eda\u2010Hermoso","sequence":"additional","affiliation":[{"name":"Navarrabiomed Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA Pamplona 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