{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:15:36Z","timestamp":1788344136799,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3601900"],"award-info":[{"award-number":["2022YFC3601900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2505500"],"award-info":[{"award-number":["2022YFC2505500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81\u2009930\u2009071"],"award-info":[{"award-number":["81\u2009930\u2009071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82\u2009072\u2009502"],"award-info":[{"award-number":["82\u2009072\u2009502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20352"],"award-info":[{"award-number":["U21A20352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82\u2009372\u2009474"],"award-info":[{"award-number":["82\u2009372\u2009474"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82\u2009302\u2009771"],"award-info":[{"award-number":["82\u2009302\u2009771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Grip strength is increasingly recognized as a modifiable and easily measurable protective factor against chronic diseases. Lower grip strength may compromise joint stability, predisposing periarticular tissues to local inflammation, which has been implicated in hand osteoarthritis (HOA), a condition affecting approximately 189 million people globally and imposing substantial health and socio\u2010economic burden. Whether lower grip strength is a risk factor for clinically relevant symptomatic HOA remains unclear. We aimed to examine the association between grip strength and incident symptomatic HOA to inform targeted preventive strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted prospective cohort studies and Mendelian randomization analyses using data from the Xiangya Osteoarthritis (XO) Study and UK Biobank. Individuals without baseline symptomatic or hospital\u2010diagnosed HOA were included. Genetic instruments for grip strength were derived from genome\u2010wide association studies. Symptomatic HOA in the XO Study was defined as the presence of radiographic HOA with symptoms, whereas hospital\u2010diagnosed HOA in the UK Biobank was ascertained through hospital inpatient records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2869 XO Study participants (5461 hands; 55.9% women; mean age of 63.2\u2009years), 166 (3.0%) hands developed incident symptomatic HOA during a mean follow\u2010up of 3.7\u2009years. Compared with the lowest grip strength quartile, odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) of symptomatic HOA in the second, third and highest quartiles were 0.51 (95% CI, 0.31\u20130.84), 0.62 (95% CI, 0.39\u20130.99) and 0.46 (95% CI, 0.28\u20130.75), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u2009=\u20090.003). Similar associations were observed among 481\u2009582 UK Biobank individuals (54.2% women; mean age of 56.4\u2009years). Mendelian randomization analyses showed ORs of genetically determined grip strength of 0.56 (95% CI, 0.40\u20130.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) for incident symptomatic HOA in the XO Study and 0.37 (95% CI, 0.25\u20130.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) for incident hospital\u2010diagnosed HOA in the UK Biobank.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher grip strength was associated with a lower risk of incident symptomatic HOA. These findings offer empirical evidence that interventions aimed at enhancing grip strength may help prevent symptomatic HOA and reduce its individual and societal burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70265","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:19:23Z","timestamp":1774948763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Higher Grip Strength Is Associated With Reduced Risk of Incident Symptomatic Hand Osteoarthritis: Data From Two Cohort Studies"],"prefix":"10.1002","volume":"17","author":[{"given":"Yilun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0John","family":"Hunter","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academic Rheumatology, School of Medicine University of Nottingham  Nottingham UK"},{"name":"Pain Centre Versus Arthritis University of Nottingham  Nottingham 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