{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:15:34Z","timestamp":1788344134926,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Longitudinal associations between C\u2010reactive protein (CRP) and handgrip strength from cohort studies remain inconsistent. We investigated the dose\u2013response association between handgrip strength and all\u2010cause mortality across different levels of systemic inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data from 20\u2009941 participants (mean age 68\u2009years \u00b19.4 SD; 43.1% men) from the Survey of Health, Ageing and Retirement in Europe (SHARE) Waves 6 to 9. CRP levels were categorized as &gt;\u20093, &gt;\u200910 and &gt;\u200925\u2009mg\/L. Time\u2010varying Cox proportional hazards regression with restricted cubic splines modeled associations between handgrip strength and all\u2010cause mortality, adjusting for age, sex, BMI, smoking, education, marital status, geographic region and medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During 4.8\u20135.3\u2009years follow\u2010up, mortalities were 14.7% (CRP &gt;\u20093\u2009mg\/L), 22.5% (CRP\u2009&gt;\u200910\u2009mg\/L) and 30.2% (CRP\u2009&gt;\u200925\u2009mg\/L). A curvilinear dose\u2013response association existed between handgrip strength and mortality across all CRP levels with a significant interaction found between CRP and handgrip strength (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0131). Using median handgrip strength as reference (30 kg for CRP &gt;\u20093\u2009mg\/L; 28\u2009kg for CRP\u2009&gt;\u200910 and &gt;\u200925\u2009mg\/L), participants at the 10th percentile showed hazard ratios of 1.84 (95% CI 1.59\u20132.14), 1.69 (95% CI 1.33\u20132.15) and 1.92 (95% CI 1.17\u20133.17), respectively. Participants at the 90th percentile demonstrated protective effects: HR 0.57 (95% CI 0.43\u20130.74), 0.50 (95% CI 0.30\u20130.82) and 0.38 (95% CI 0.17\u20130.87).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Handgrip strength demonstrates a strong inverse dose\u2013response association with mortality across varying inflammation levels. Protective effects persist even with elevated inflammatory markers, supporting handgrip strength as an accessible biomarker for mortality risk stratification in older adults regardless of inflammatory status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70272","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:10:38Z","timestamp":1774653038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dose\u2013Response Association Between Handgrip Strength and All\u2010Cause Mortality Across Different Levels of Systemic Inflammation"],"prefix":"10.1002","volume":"17","author":[{"given":"Andrea","family":"Tur\u2010Boned","sequence":"first","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH\u2010RG), Department of Physiotherapy University of Valencia  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