{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:03:21Z","timestamp":1784887401814,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia has emerged as a potential prognostic factor in patients with advanced prostate cancer (PCa), requiring interventions for its prevention and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to systematically identify, critically assess and synthesize the available evidence on the effectiveness and safety of interventions for preventing or treating sarcopenia in advanced PCa patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, Embase and Web of Science were searched. Randomized and non\u2010randomized controlled trials or longitudinal observational studies with a control group focusing on PCa patients aged 60\u2009years and older were considered. Study selection, data extraction and risk\u2010of\u2010bias assessment of the included studies were performed in duplicate. When possible, pooled effect estimates were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091275) were included. Resistance training (RT) (MD\u2009=\u20093.22\u2009kg; 95% CI 0.69, 5.75) and the use of antimyostatin peptibody (MD\u2009=\u20092.2\u2009kg; SE 0.8%) demonstrated statistically significant prevention of lean body mass loss in men undergoing androgen deprivation therapy (ADT). Exercise improved leg press (MD\u2009=\u200925.17\u2009kg; 95% CI [8.71, 41.62]), leg extension (MD\u2009=\u20099.63\u2009kg; 95% CI [4.83, 14.42]), seated row (MD\u2009=\u20094.38\u2009kg; 95% CI [1.54, 7.22]) and chest press strength (MD\u2009=\u20091.70\u2009kg; 95% CI [\u22121.48, 4.88]) and enhanced patients' physical functioning in chair sit\u2010to\u2010stand tests (MD\u2009=\u2009\u22121.02\u2009kg; 95% CI [\u22121.70, \u22120.34]). RT improved health\u2010related quality of life (HRQoL) in both general and specific domains and also reduced somatization (MD\u2009=\u2009\u22120.69\u2009kg; 95% CI [\u22121.32, \u22120.07]) and psychological distress (MD\u2009=\u2009\u22121.63\u2009kg; 95% CI [\u22123.10, \u22120.15]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings highlight the potential benefits of RT and selected pharmacological interventions on muscle\u2010related and functional outcomes. However, the significant heterogeneity and lack of comprehensive outcome reporting underscore the need for more standardized and long\u2010term research through larger, well\u2010designed randomized controlled trials with standardized measurement methods to draw conclusive evidence and enhance the reliability and applicability of findings in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70290","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:48:16Z","timestamp":1778042896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and Safety of Interventions for Sarcopenia in Advanced Prostate Carcinoma: Systematic Review"],"prefix":"10.1002","volume":"17","author":[{"given":"Pedro","family":"de Pablos\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Urology Instituto Valenciano de Oncolog\u00eda (IVO)  Valencia Spain"},{"name":"Canry Islands Health Research Institute Foundationa (FIISC)  Las Palms de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aythami","family":"de Armas\u2010Castellano","sequence":"additional","affiliation":[{"name":"Canary Islands Health Research Institute Foundation (FIISC)  El Rosario Santa Cruz de Tenerife Spain"},{"name":"Evaluation Unit of the Canary Islands Health Service (SESCS)  El Rosario Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Infante\u2010Ventura","sequence":"additional","affiliation":[{"name":"Canary Islands Health Research Institute Foundation (FIISC)  El Rosario Santa Cruz de Tenerife Spain"},{"name":"Evaluation Unit of the Canary Islands Health Service (SESCS)  El Rosario Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasmania","family":"del Pino\u2010Sede\u00f1o","sequence":"additional","affiliation":[{"name":"Canary Islands Health Research Institute Foundation (FIISC)  El Rosario Santa Cruz de Tenerife Spain"},{"name":"Evaluation Unit of the Canary Islands Health Service (SESCS)  El Rosario Santa Cruz de Tenerife Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Rueda","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Medical Oncology Intercenter Unit Regional and Virgen de la Victoria University Hospitals, IBIMA  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo B.","family":"Pedrianes\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition University Hospital of Gran Canaria Doctor Negr\u00edn  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A. 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