{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:03:05Z","timestamp":1784887385452,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bariatric surgery is an effective treatment for obesity but induces substantial muscle loss, potentially leading to sarcopenia. Omega\u20103 fatty acids have been associated with improved muscle metabolism, but their effect in the postoperative period of bariatric surgery remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A triple\u2010blind randomized clinical trial following CONSORT guidelines. Patients undergoing bariatric surgery were randomly assigned to receive omega\u20103 supplementation (2000\u2009mg\/day of EPA\u2009+\u2009DHA) or placebo (sunflower oil) for 90\u2009days, including 15\u2009days preoperatively and 75\u2009days postoperatively. Assessments were performed at baseline, 45\u2009days and 105\u2009days after the start of supplementation. Outcomes included skeletal muscle mass (bioelectrical impedance [BIA]), handgrip strength (HGS) and functional performance (timed up and go [TUG] test).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010eight patients were randomized (81% women; mean age 38.2\u2009\u00b1\u20099.9\u2009years; mean body mass index [BMI]: 41.1\u2009\u00b1\u20094.6\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). At baseline, intervention and control groups were comparable in weight (112.7\u2009\u00b1\u200919.1 vs. 113.0\u2009\u00b1\u200917.9\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.946), muscle mass (33.5\u2009\u00b1\u20097.5 vs. 32.5\u2009\u00b1\u20097.3\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.603), HGS (33.3\u2009\u00b1\u20099.6 vs. 35.4\u2009\u00b1\u200910.2\u2009kgf;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.428) and TUG (8.7\u2009\u00b1\u20093.0 vs. 8.7\u2009\u00b1\u20091.8\u2009s;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.912). Between baseline and 105\u2009days, muscle mass decreased significantly in both groups (\u22123.1\u2009\u00b1\u20090.3\u2009kg; \u22122.2\u2009\u00b1\u20090.5\u2009kg; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), without interaction between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.300). HGS remained stable (\u0394 \u22120.8 to +2.3\u2009kgf; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.364), and TUG performance did not change significantly (\u0394 0.0\u20131.1\u2009s; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.106). Weight loss was marked in both groups (\u221219.3\u2009\u00b1\u20091.9 vs. \u221217.7\u2009\u00b1\u20092.1\u2009kg; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The incidence of gastrointestinal symptoms \u2265\u20093 times\/week was similar (34.5% vs. 13.6% at 45\u2009days;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.114). No serious adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Omega\u20103 supplementation (2000\u2009mg\/day) during the perioperative period of bariatric surgery did not prevent muscle mass loss nor improve muscle strength or functional performance within 105\u2009days of follow\u2010up. Although the supplementation was safe and well tolerated, it did not demonstrate efficacy in mitigating early sarcopenia\u2010related outcomes in this population.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov: NCT06494566\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70321","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:02:06Z","timestamp":1781478126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Omega\u20103 Supplementation in Sarcopenia After Bariatric Surgery: A Triple\u2010Blind Randomized Controlled Clinical Trial"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-4008","authenticated-orcid":false,"given":"Andr\u00e9 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