{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:42:45Z","timestamp":1790786565416,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dietary and pharmacologic weight loss can reduce skeletal muscle. Whether calcium beta\u2010hydroxy\u2010beta\u2010methylbutyrate (CaHMB)\u2010enriched supplementation preserves muscle while promoting fat loss in adults with obesity remains uncertain. We evaluated a CaHMB\u2010enriched nutritional supplement during energy restriction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized, double\u2010blind, controlled trial, 102 Chinese adults with obesity (body mass index [BMI]\u2009\u2265\u200928\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) were assigned 1:1 to a CaHMB\u2010enriched nutritional supplement (65\u2009g\/day powder containing 3.0\u2009g\/day CaHMB and 24\u2009g\/day protein) or an energy\u2010matched maltodextrin control for 12\u2009weeks, alongside standardized dietary energy restriction. The primary outcome was change in whole\u2010body skeletal muscle mass (SMM) by multifrequency bioelectrical impedance analysis. Secondary outcomes included visceral fat area (VFA), body fat mass (BFM), basal metabolic rate (BMR), physical function and metabolic biomarkers. ITT analyses adjusted for baseline values, age, sex, dietary intake and physical activity changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants had a mean age of 36.8\u2009\u00b1\u20095.2\u2009years, a mean BMI of 32.2\u2009\u00b1\u20093.3\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and 37.3% (38\/102) were female. The CaHMB group maintained SMM (median +0.7\u2009kg; IQR\u2009= \u22120.2 to 2.0), whereas the control group lost SMM (median = \u22120.6\u2009kg; IQR\u2009= \u22121.9 to \u22120.1; between\u2010group difference 1.3\u2009kg; 95% CI = 0.5 to 1.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). More CaHMB participants gained \u2265\u20090.5\u2009kg SMM (52.9% vs. 11.8%; OR = 8.44; 95% CI = 3.23 to 25.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). CaHMB also produced greater reductions in VFA (adjusted mean difference [AMD] = \u221214.9\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI = \u221225.1 to \u22124.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and BFM (AMD = \u22124.9\u2009kg; 95% CI = \u22126.8 to \u22123.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), preserved BMR (difference 62.0\u2009kcal\/day; 95% CI = 35.0 to 89.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and reduced fasting glucose more than control (difference \u22120.4\u2009mmol\/L; 95% CI = \u22120.8 to \u22120.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). No adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During dietary weight loss, CaHMB\u2010enriched supplementation preserved SMM and produced greater visceral and total fat reductions. Because the intervention also contained protein, longer factorial trials are needed to isolate CaHMB\u2010specific effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT04953936\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70343","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:14:22Z","timestamp":1784006062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Calcium Beta\u2010Hydroxy\u2010Beta\u2010Methylbutyrate\u2010Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"17","author":[{"given":"Jiaojiao","family":"Jiang","sequence":"first","affiliation":[{"name":"Rehabilitation Center West China Hospital, Sichuan University  Chengdu China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Liang","sequence":"additional","affiliation":[{"name":"Rehabilitation Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Rehabilitation Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Jiang","sequence":"additional","affiliation":[{"name":"West China Fourth Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Gerontology and Geriatrics West China Hospital, Sichuan University  Chengdu China"},{"name":"Institute of Respiratory Health and Multimorbidity West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01210-8"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19897"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00351-9"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02538-7"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2301972"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-024-01041-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00316-4"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01106-8"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00045-0"},{"issue":"6","key":"e_1_2_13_11_1","first-page":"428","article-title":"Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement","volume":"10","author":"Donini L. 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