{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:20:02Z","timestamp":1787746802119,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572522"],"award-info":[{"award-number":["82572522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Electroacupuncture (EA) treatment has been utilized for recovery from neuromuscular\u2010related diseases and may play a significant role in the treatment of sarcopenia. This interventional, randomized controlled clinical study aims to explore the efficacy of EA treatment in maintenance haemodialysis (MHD) patients with sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six participants with sarcopenia undergoing MHD were randomly divided into the control group and the EA group. The participants in the EA group received a total of 24 treatments, each lasting 30\u2009min, and were administered three times per week. Participants in the control group were instructed to continue their current lifestyle and treatment plans. The assessments were conducted at baseline and after 8\u2009weeks. Statistical analysis was performed using two\u2010way analysis of covariance (ANCOVA) adjusted according to gender and baseline values. Repeated measures analysis of variance (ANOVA) was used to assess EA effects, reporting main effects and the time\u2009\u00d7\u2009group interaction with partial eta squared (\u03b7\n                      <jats:sup>2<\/jats:sup>\n                      <jats:italic>p<\/jats:italic>\n                      ) effect sizes. The primary outcome was 6\u2010m gait speed; the secondary outcomes were skeletal muscle mass index (SMI) and handgrip strength. Fasting blood samples were collected, and serum metabolomics using the liquid chromatography\u2013mass spectrometry method was employed to reveal metabolic changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One participant from the EA group dropped out, and 35 participants were included in the analysis, aged (59.06\u2009\u00b1\u200911.69) years, including 22 men and 13 women. After intervention, the 6\u2010m gait speed of the EA group increased (\u0394\u2009=\u20090.10\u2009\u00b1\u20090.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas that of the control group decreased (\u0394\u2009=\u2009\u22120.06\u2009\u00b1\u20090.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). The handgrip strength of the EA group increased (\u0394\u2009=\u20090.68\u2009\u00b1\u20090.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), whereas that of the control group decreased (\u0394\u2009=\u2009\u22120.76\u2009\u00b1\u20091.19;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). The SMI in the EA group increased (\u0394\u2009=\u20090.19\u2009\u00b1\u20090.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), although there was no significant difference in the control group. No serious adverse events were observed during the EA treatment. The results of serum metabolomics indicated that a total of 127 differentially expressed metabolites were identified (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, VIP &gt;\u20091), including 35 up\u2010regulated metabolites and 92 down\u2010regulated metabolites. KEGG pathway enrichment analysis showed that glycerophospholipid metabolism, linoleic acid metabolism and other pathways related to lipid metabolism were significantly changed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EA treatment was an effective therapy for sarcopenia in patients undergoing MHD. Its therapeutic effect may be related to the positive regulation of systemic metabolism (including amino acid and lipid profiles).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70345","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:32:49Z","timestamp":1784518369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture Treatment on Sarcopenia in Patients Undergoing Maintenance Haemodialysis: An Effective Therapy"],"prefix":"10.1002","volume":"17","author":[{"given":"Ruoxin","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Nephrology, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Nephrology Taizhou Fourth People's Hospital  Taizhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuolin","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyun","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Zhongda Hospital, School of Medicine Southeast University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.12.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00550-w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2022.2128373"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12890"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051538"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12926"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac220"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051293"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2022.01039"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010044"},{"issue":"12","key":"e_1_2_10_12_1","first-page":"973","article-title":"Effects of Electroacupuncture on Proangiogenesis Process and Protein Turnover in a Mouse Model of Sarcopenia","volume":"45","author":"Zhu Z. 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