{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:53:47Z","timestamp":1791374027467,"version":"4.3.1"},"reference-count":120,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%\u201310% across treatment courses, while chemotherapy\u2010induced cognitive impairment affects up to one\u2010third of patients. Emerging evidence indicates that chemotherapeutic agents impair mitochondrial function in peripheral tissues, including skeletal muscle, increasing systemic oxidative stress and inflammatory cytokines. These factors may promote oxidative stress and inflammation within the brain, particularly in the hippocampus, contributing to neuronal mitochondrial dysfunction, apoptosis and cognitive decline. Skeletal muscle may therefore represent an important component within a broader muscle\u2013brain axis linking chemotherapy\u2010induced metabolic dysfunction with brain health. Targeted exercise improves skeletal muscle mitochondrial function, reduces systemic inflammation and oxidative stress and modulates multiple exercise\u2010responsive signalling pathways, including myokines such as brain\u2010derived neurotrophic factor and irisin. Collectively, these adaptations may contribute to improved neuronal health, neurogenesis and cognitive function. Understanding these interconnected mechanisms may inform exercise strategies to mitigate chemotherapy\u2010related cognitive impairment.<\/jats:p>","DOI":"10.1002\/jcsm.70394","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:18:56Z","timestamp":1791371936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemotherapy\u2010Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle\u2010Brain Mechanistic Framework With Implications for Exercise Oncology"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0075-7500","authenticated-orcid":false,"given":"SoYoung","family":"Ahn","sequence":"first","affiliation":[{"name":"Institute of Sports Science, Department of Physical Education Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-2281","authenticated-orcid":false,"given":"Daniel A.","family":"Galvao","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-1597","authenticated-orcid":false,"given":"Dennis R.","family":"Taaffe","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-2670","authenticated-orcid":false,"given":"Dong Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, College of Medicine Seoul National University  Seoul Republic of Korea"},{"name":"Institute on Aging Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-4022","authenticated-orcid":false,"given":"Carolyn","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-2124","authenticated-orcid":false,"given":"Jihee","family":"Min","sequence":"additional","affiliation":[{"name":"National Cancer Survivorship Center, National Cancer Control Institute National Cancer Center  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8825-6259","authenticated-orcid":false,"given":"Wook","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Sports Science, Department of Physical Education Seoul National University  Seoul Republic of Korea"},{"name":"Institute on Aging Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-6129","authenticated-orcid":false,"given":"Robert U.","family":"Newton","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research 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