{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:33:50Z","timestamp":1793010830905,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103021"],"award-info":[{"award-number":["82103021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M721725"],"award-info":[{"award-number":["2022M721725"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J cachexia sarcopenia muscle"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cachexia in oesophageal squamous cell carcinoma is driven by systemic inflammation and malnutrition and is associated with poor survival. We evaluated whether circulating miRNAs can identify ESCC cachexia and reflect its inflammatory\u2010nutritional phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 126 participants: 42 healthy controls and 84 treatment\u2010na\u00efve patients with ESCC, equally classified as noncachectic or cachectic using international consensus criteria. Small\u2010RNA sequencing in a discovery subset (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094\/group) was followed by cohort\u2010wide qRT\u2010PCR. Exploratory within\u2010cohort discrimination was assessed by receiver operating characteristic (ROC) analysis; survival associations were evaluated using Kaplan\u2013Meier and univariate Cox analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cachectic ESCC was characterized by lower albumin, total protein and prealbumin and higher IL\u20106, TNF\u2010\u03b1, CRP and IL\u20101\u03b2 than noncachectic ESCC (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Circulating hsa\u2010miR\u20105187\u20105p and hsa\u2010miR\u20104433b\u20103p increased stepwise from controls to noncachectic and cachectic ESCC. For noncachectic versus cachectic ESCC, AUCs were 0.8594 and 0.8175, respectively (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001); for controls versus cachectic ESCC, AUCs were 0.9439 and 0.8889. Cachexia was associated with shorter overall survival (HR 1.708, 95% CI 1.011\u20132.887;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), as were high miR\u20105187\u20105p (HR 3.635) and miR\u20104433b\u20103p (HR 3.190) expression. Correlations with inflammatory markers and albumin were weak to moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>hsa\u2010miR\u20105187\u20105p and hsa\u2010miR\u20104433b\u20103p are candidate circulating indicators of ESCC\u2010associated cachexia and its inflammatory\u2010metabolic milieu. Their discriminatory and prognostic performance remains exploratory because analyses were conducted within the same cohort and were not comprehensively adjusted for tumour stage or other clinicopathological factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcsm.70409","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:15:29Z","timestamp":1792664129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating MicroRNAs Reflect Systemic Inflammation and Metabolic Dysfunction in Oesophageal Squamous Cell Carcinoma\u2013Associated Cachexia"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0294-0084","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Southeast University Affiliated Nantong First People's Hospital  Nantong 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Southeast University Affiliated Nantong First People's Hospital  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-7014","authenticated-orcid":false,"given":"Yiming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Southeast University Affiliated Nantong First People's Hospital  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9897-6789","authenticated-orcid":false,"given":"Shengguang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Southeast University Affiliated Nantong First People's Hospital  Nantong 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