{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:24:54Z","timestamp":1769815494239,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T00:00:00Z","timestamp":1177372800000},"content-version":"vor","delay-in-days":5592,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Chemical Tech &amp; Biotech"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Novel azo\u2010dyes have been synthesized by diazotization of 4\u2010amino benzene\u20104\u2032\u2010(substituted heterocyclo) sulphonamide derivatives and coupling with 1\u2010oxa\u20104\u2010thia\u2010spiro[4,4]nonan\u20102\u2010one (I) and\/or with l\u2010oxa\u20104\u2010thia\u2010spiro[4,5]decan\u20102\u2010one (I\u2032) in acid medium to give the corresponding 3\u2010azo\u2010(4\u2032\u2010substituted benzenesulphonamido)\u2010l\u2010oxa\u20104\u2010thia\u2010spiro[4,4]nonan\u20102\u2010one (II\u2010IX) and\/or l\u2010oxa\u20104\u2010thia\u2010spiro[4,5]decan\u20102\u2010one (II\u2032\u2010IX\u2032] as spiro\u2010ligands. Treatment of these ligands with metal salts of iron (Fe<jats:sup>3+<\/jats:sup>), copper (Cu<jats:sup>2+<\/jats:sup>) and mercury (Hg<jats:sup>2+<\/jats:sup>) as chlorides in ethanolic solution furnished the corresponding metal chelates (II<jats:sub>a\u2010c<\/jats:sub>\u2010IX<jats:sub>a\u2010c<\/jats:sub>) and\/or (II\u2032<jats:sub>a\u2010c<\/jats:sub>\u2010IX\u2032<jats:sub>a\u2010c<\/jats:sub>). The compounds were tested <jats:italic>in vitro<\/jats:italic> for antimicrobial activity to study the structure\u2010activity relationship.<\/jats:p>","DOI":"10.1002\/jctb.280550304","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T16:18:15Z","timestamp":1278346695000},"page":"217-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Spiroheterocyclic system. Part IV: Novel azo dye sulpha drugs of spiroheterocyclic naphthenes"],"prefix":"10.1002","volume":"55","author":[{"given":"Ibrahim M. A.","family":"Awad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali A. Abdel","family":"Hafez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahr F.","family":"El\u2010Zohry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(88)85184-0"},{"issue":"4","key":"e_1_2_1_3_2","first-page":"643","volume":"24","author":"Zefirov N. S.","year":"1988","journal-title":"Zh. Org. 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