{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T17:00:32Z","timestamp":1725469232816},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,2,19]],"date-time":"2002-02-19T00:00:00Z","timestamp":1014076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Transcranial Doppler sonography (TCD) is an established method for assessing changes in blood flow velocity (BFV) coupled to brain activity. Our objective was to investigate whether walking induces measurable changes in BFV in healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Changes in BFV in both middle cerebral arteries (MCAs) of 40 healthy adult subjects during walking on a treadmill were measured using bilateral TCD. In 8 of the 40 subjects, 1 anterior cerebral artery (ACA) was monitored simultaneously with the contralateral MCA. The percentage increase in BFV (BFVI%) compared with the baseline velocity (V<jats:sub>0<\/jats:sub>), the percentage decrease in BFV (BFVD%) compared with the V<jats:sub>0<\/jats:sub>, and the normalized ACA\u2010MCA ratio were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall mean (\u00b1 standard deviation [SD]) V<jats:sub>0<\/jats:sub> was 59.9 \u00b1 11.6 cm\/second in the left MCA and 60.1 \u00b1 12.9 cm\/second in the right MCA. Women had higher V<jats:sub>0<\/jats:sub> values than men had. Walking evoked an initial mean overall BFVI% in both left (8.4 \u00b1 5.1%) and right MCAs (9.1 \u00b1 5.1%), followed by a decrease to below baseline values in 38 of 40 subjects. A statistically significant increase of the normalized ACA\u2010MCA ratio was measured, indicating that changes in BFV in the ACA territory were coupled to brain activation during walking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of functional TCD showed different changes in BFV in the ACAs and MCAs during walking. This method may be an interesting tool for monitoring progress in patients with motor deficits of the legs, such as paresis. \u00a9 2002 Wiley Periodicals, Inc. 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