{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:46:20Z","timestamp":1758991580677},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to document the characteristic sonographic findings of clonorchiasis for the diagnosis of active infection in an endemic area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a village in northeastern China, residents underwent fecal examinations for detection of <jats:italic>Clonorchis sinensis<\/jats:italic> eggs. Shortly thereafter, residents were examined with abdominal sonography. An experienced radiologist performed the sonographic examinations and analyzed the findings. Subjects whose fecal examinations were positive for eggs were considered to have active clonorchiasis; those whose examinations were negative for eggs were used as control subjects. The distinguishing sonographic features of active clonorchiasis were identified by stepwise logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 457 subjects; fecal examinations revealed <jats:italic>C. sinensis<\/jats:italic> eggs in 316 and no eggs in 141. Four sonographic findings distinguished subjects with active clonorchiasis from control subjects: increased periductal echogenicity (<jats:italic>p<\/jats:italic> &lt; 0.001; <jats:italic>R<\/jats:italic> = 0.11; sensitivity, 35%; specificity, 91%), floating echogenic foci in the gallbladder (<jats:italic>p<\/jats:italic> &lt; 0.001; <jats:italic>R<\/jats:italic> = 0.09; sensitivity, 28%; specificity, 94%), diffuse dilatation of the intrahepatic bile ducts (<jats:italic>p<\/jats:italic> &lt; 0.01; <jats:italic>R<\/jats:italic> = 0.03; sensitivity, 67%; specificity, 48%), and gallbladder distention (<jats:italic>p<\/jats:italic> &lt; 0.05; <jats:italic>R<\/jats:italic> = 0.02; sensitivity, 3%; specificity, 100%), in decreasing order of significance. Among these 4 sonographic findings, increased periductal echogenicity and floating echogenic foci in the gallbladder were more significantly associated with active infection than were the other 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased periductal echogenicity and floating echogenic foci in the gallbladder were identified as the 2 most significant findings for the sonographic diagnosis of active <jats:italic>C. sinensis<\/jats:italic> infection. \u00a9 2003 Wiley Periodicals, Inc. J Clin Ultrasound 32:17\u201323, 2004<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.10216","type":"journal-article","created":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T21:01:30Z","timestamp":1072818090000},"page":"17-23","source":"Crossref","is-referenced-by-count":31,"title":["Sonographic findings of active <i>Clonorchis sinensis<\/i> infection"],"prefix":"10.1002","volume":"32","author":[{"given":"Dongil","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Tae","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hoon","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Yull","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Jong","family":"Rim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,30]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"7","article-title":"Progress in assessment of morbidity due to Clonorchis sinensis infection: a review of recent literature","volume":"91","author":"Chen M","year":"1994","journal-title":"Trop Dis Bull"},{"key":"e_1_2_1_3_2","first-page":"47","article-title":"Epidemiology and control of clonorchiasis in Korea","volume":"28","author":"Rim HJ","year":"1997","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-001-0177-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870160907"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.4.761"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1994.32.4.223"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1998.36.4.249"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1987.25.2.110"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1999.37.2.77"},{"key":"e_1_2_1_11_2","first-page":"108","article-title":"The ultrasound survey of gallstone diseases of patients infected with Clonorchis sinensis in southern Taiwan","volume":"92","author":"Hou MF","year":"1989","journal-title":"J Trop Med Hyg"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.155.5.2120925"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(99)90855-3"},{"key":"e_1_2_1_14_2","first-page":"275","article-title":"Field evaluation of an improved Kato\u2010Katz thick smear technique for quantitative determination of helminth eggs in faeces","volume":"46","author":"Odongo\u2010Aginya EI","year":"1995","journal-title":"Trop Med Parasitol"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcu.10216","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.10216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T04:22:43Z","timestamp":1696652563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.10216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,30]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/jcu.10216"],"URL":"https:\/\/doi.org\/10.1002\/jcu.10216","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,30]]}}}