{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:46:00Z","timestamp":1757699160596},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T00:00:00Z","timestamp":1133481600000},"content-version":"vor","delay-in-days":4687,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As a result of numerous conflicting reports, we designed a prospective controlled study to determine the inherent risk of aneuploidy with second\u2010trimester fetal choroid plexus cysts. Our controls were patients who had ultrasonography and genetic amniocentesis, between 15 weeks and 22 weeks, menstrual age, by the same sonologist on the same day as a study subject with a choroid plexus cyst. Sixty\u2010three cases of fetal choroid plexus cysts were detected in 3247 second\u2010trimester examinations (1.9%). Six chromosomally abnormal fetuses [Trisomy 18 (3), Down syndrome (2), Klinefelter syndrome] were found in the cyst group (9.5%) with only one Trisomy 21 among the controls (0.5%) (p &lt;.002). Of note, 5 of 21 (23.8%) fetuses with cysts greater than 5 mm in diameter had aneuploidy, as compared with only 1 of 42 (2.4%) chromosomal anomalies with smaller cysts (p &lt;.02). We conclude that fetal choroid plexus cysts are an independent risk factor for chromosomal anomalies; genetic counseling and prenatal chromosomal analysis are indicated. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/jcu.1870210205","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:02:38Z","timestamp":1172696558000},"page":"103-108","source":"Crossref","is-referenced-by-count":33,"title":["Fetal choroid plexus cysts: An independent risk factor for chromosomal anomalies"],"prefix":"10.1002","volume":"21","author":[{"given":"Manuel","family":"Porto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Warneke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Kirk A.","family":"Keegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040207"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90824-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90192-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090310"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.175.3.2188298"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)91451-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1991.10.5.255"},{"key":"e_1_2_1_9_2","first-page":"185","article-title":"Choroid plexus cysts in the fetus: A benign anatomic variant or pathologic entity? Report of 41 cases and review of the literature","volume":"72","author":"Chitkara U","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_10_2","first-page":"585","article-title":"Prenatal diagnosis of cysts of the fetal choroid plexus","volume":"72","author":"Clark SL","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320270428"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90434-1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.151.6.1179"},{"key":"e_1_2_1_14_2","unstructured":"DevoreGR PlattLD AlfiO et al:Fetal echocardiography: An option for the detection of chromosomal aneuploidy for women over 34 who chose not to undergo genetic amniocentesis because of fear of complications from the procedure. [abstract]. Proceedings of the ninth annual meeting of the Society of Perinatal Obstetricians New Orleans LA February 2\u20134 1989."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91304-U"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90022-5"},{"key":"e_1_2_1_17_2","first-page":"302","article-title":"Reply to \u201eFetal choroid plexus cysts\u201d\ufe01 (letter)","volume":"73","author":"Clark SL","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1989.8.2.77"},{"key":"e_1_2_1_19_2","first-page":"257","article-title":"Choroid plexus cysts in fetuses with Trisomy 18","volume":"73","author":"Fitzsimmons J","year":"1989","journal-title":"Obstet Gynecol"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcu.1870210205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.1870210205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T19:11:56Z","timestamp":1698174716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.1870210205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1002\/jcu.1870210205"],"URL":"https:\/\/doi.org\/10.1002\/jcu.1870210205","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}