{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:49:04Z","timestamp":1762760944406},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the usefulness of contrast\u2010enhanced sonography (CEUS) in the diagnosis of small hepatocellular carcinoma (HCC) measuring \u22642 cm in diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 104 focal liver lesions measuring \u22642 cm in 104 consecutive patients who were enrolled for baseline sonography (BUS) and CEUS examination (49 HCCs, 55 non\u2010HCCs). A real\u2010time, contrast\u2010specific mode of contrast pulse sequencing and a sulphur hexafluoride\u2010filled microbubble contrast agent were used for CEUS. The diagnostic performances of BUS and CEUS in differentiating focal liver lesions (HCC or non\u2010HCC) were analyzed and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On CEUS, 43 (87.8%) of the 49 HCC lesions were hyperenhanced, 5 (10.2%) were isoenhanced, and 1 (2%) was hypoenhanced during the arterial phase when compared with adjacent liver tissue. Thirty\u2010nine (79.6%) HCCs exhibited washout from the portal phase to the late phase. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy before and after contrast agent administration were 28.6% (14\/49) versus 79.6% (39\/49) (<jats:italic>p<\/jats:italic> &lt; 0.001), 94.5% (52\/55) versus 92.7% (51\/55) (<jats:italic>p<\/jats:italic> &gt; 0.05), 82.4% (14\/17) versus 90.7% (39\/43) (<jats:italic>p<\/jats:italic> &gt; 0.05), 59.8% (52\/87) versus 90.7% (39\/43) (<jats:italic>p<\/jats:italic> &lt; 0.01), and 63.5% (66\/104) versus 86.5% (90\/104) (<jats:italic>p<\/jats:italic> &lt; 0.001), respectively. No significant difference in diagnostic performance of CEUS was found between lesions measuring \u22641.5 cm and those 1.6\u20132 cm and between lesions located at a depth of \u22646 cm from the skin and those located deeper.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CEUS significantly improved the diagnostic performance in characterization of small HCCs \u22642 cm compared with BUS. \u00a9 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2008<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.20433","type":"journal-article","created":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T23:16:30Z","timestamp":1198019790000},"page":"257-266","source":"Crossref","is-referenced-by-count":28,"title":["Contrast\u2010enhanced sonography in the diagnosis of small hepatocellular carcinoma \u22642 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