{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:40:51Z","timestamp":1770702051622,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Diabetes mellitus (DM) is one of the leading risk factors for cerebrovascular diseases. Both macro\u2010 and microvascular damage may occur. The aim of the present work was to assess intima\u2010media thickness as well as cerebral vasoreactivity in patients suffering from type 1 diabetes mellitus (IDDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intima\u2010media thickness and resting middle cerebral artery blood flow velocity was measured in 33 IDDM patients and 31 healthy controls. After baseline investigations, 30 seconds of breath holding (BH) and 60 seconds of voluntary hyperventilation (HV) were performed by the subjects. Transcranial Doppler measurements were performed in each case after vasodilatory (BH) and vasoconstrictor (HV) stimuli. Cerebrovascular reactivity was expressed as the percentage of change of the middle cerebral mean blood flow velocity after BH or HV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IDDM patients showed a significantly larger intima\u2010media thickness (0.1 \u00b1 0.02 mm) than healthy controls (0.06 \u00b1 0.006 mm,<jats:italic>p<\/jats:italic>&lt; 0.001). Cerebrovascular reactivity after BH was less intensive in diabetic patients (19.3 \u00b1 16.1%) than that of the control subjects (38.7 \u00b1 22.8%,<jats:italic>p<\/jats:italic>&lt; 0.01). Similarly, HV induced a less\u2010pronounced decrease of cerebral blood flow velocity in diabetic subjects (\u201330.1 \u00b1 13.2%) than in nondiabetics (\u201337.6 \u00b1 17.0%,<jats:italic>p<\/jats:italic>&lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results refer to early macro\u2010 and microangiopathic involvement of the cerebral vessels, which develop in parallel with angiopathies of the other organs, such as nephropathy and retinopathy. Further prospective studies are needed to clarify the role of these macro\u2010 and microangiopathic changes in the development of cerebrovascular complications in patients suffering from DM. \u00a9 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.20617","type":"journal-article","created":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T16:18:18Z","timestamp":1249402698000},"page":"451-456","source":"Crossref","is-referenced-by-count":9,"title":["Carotid intima\u2010media thickness and cerebrovascular reactivity in long\u2010term type 1 diabetes mellitus"],"prefix":"10.1002","volume":"37","author":[{"given":"P\u00e9ter","family":"Sir\u00f3","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csilla","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Katona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Antek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Koll\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Settakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"F\u00fclesdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610030206"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68341-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.5.709"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6133.325"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.2337\/diab.46.11.1840","article-title":"Impairment of cerebrovascular reactivity in long\u2010term type 1 diabetes","volume":"46","author":"F\u00fclesdi B","year":"1997","journal-title":"Diabetes"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400103"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000069496"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(99)00044-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2002.tb00129.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2001.tb00030.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1054\/ijoa.2002.0950"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000097018"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.11.1986"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.9.1297"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.5.1111"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067219700700207"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000108217"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000090471.28672.65"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2337\/diab.40.6.653","article-title":"Pathobiology of endothelial and other vascular cells in diabetes mellitus","volume":"40","author":"Lorenzi M","year":"1991","journal-title":"Diabetes"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0022-3565(25)23513-3","article-title":"Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in native and streptozocin\u2010induced diabetic rats","volume":"249","author":"Kamata K","year":"1989","journal-title":"J Phamacol Exp Ther"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcu.20617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.20617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T16:41:55Z","timestamp":1739292115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.20617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,4]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1002\/jcu.20617"],"URL":"https:\/\/doi.org\/10.1002\/jcu.20617","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,4]]}}}