{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:14:02Z","timestamp":1783473242549,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T00:00:00Z","timestamp":1340323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background.<\/jats:title><jats:p>Left atrial appendage (LAA) may be a source of thrombi in patients with dilated cardiomyopathy at sinus rhythm. The objectives of our study were to assess the prevalence of intracardiac left chamber thrombus and\/or spontaneous echo contrast and to identify clinical and echocardiographic predictors for left ventricle (LV), left atrium (LA), and\/or LAA thrombus formation, particularly as regard to LV, LA, and LAA size, in heart failure patients at sinus rhythm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We included 45 patients with dilated cardiomyopathy of ischemic or idiopathic origin with mild to moderate systolic dysfunction, who were at sinus rhythm and without anticoagulation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Mean left ventricular end diastolic diameter was 64.9 \u00b1 6.1 mm, and mean LV ejection fraction was 39.9 \u00b1 7.3%. LV thrombus was found in 13.3% of patients and LAA thrombus in 68. 9%. Left ventricular end diastolic diameter was correlated with LA volume (<jats:italic>r<\/jats:italic> = 0.59, <jats:italic>p<\/jats:italic> &lt; 0.0001) and LV thrombus (<jats:italic>r<\/jats:italic> = 0.38, <jats:italic>p<\/jats:italic> = 0.005). LA volume was correlated with LAA maximal area (<jats:italic>r<\/jats:italic> = 0.34, <jats:italic>p<\/jats:italic> = 0.01), which was an independent predictor for LAA thrombus formation (<jats:italic>p<\/jats:italic> = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Dilation of left cardiac chambers offers a suitable terrain for thrombus formation. The high probability of LAA thrombosis should be kept in mind when designing the treatment strategy for patients with dilated cardiomyopathy at sinus rhythm. \u00a9 2012 Wiley Periodicals, Inc. J Clin Ultrasound 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.21953","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T17:04:52Z","timestamp":1340384692000},"page":"38-45","source":"Crossref","is-referenced-by-count":37,"title":["Prevalence of left chamber cardiac thrombi in patients with dilated left ventricle at sinus rhythm: The role of transesophageal echocardiography"],"prefix":"10.1002","volume":"41","author":[{"given":"Aurora","family":"Bakalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica","family":"Georgievska\u2010Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dardan","family":"Ko\u00e7inaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebi","family":"Musliu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agim","family":"Krasniqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ejup","family":"Pllana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1520-765X(01)90035-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.2.314"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90310-U"},{"key":"e_1_2_6_5_2","first-page":"90","article-title":"The influence of left ventricular diameter on left atrial appendage size and thrombus formation in patients with dilated cardiomyopathy","volume":"38","author":"Bakalli A","year":"2010","journal-title":"Turk Kardiyol Dern Ars"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-11-199512010-00001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70498-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/hrt.82.5.547","article-title":"Left atrial appendage: structure, function, and role in thromboembolism","volume":"82","author":"Al\u2010Saddy NM","year":"1999","journal-title":"Heart"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.223"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102975"},{"key":"e_1_2_6_12_2","first-page":"91","article-title":"Key data elements and definitions for cardiac imaging. A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Cardiac Imaging)","volume":"53","author":"ACC\/AHA\/ACR\/ASE\/ASNC\/HRS\/NASCI\/RSNA\/SAIP\/ SCAI\/SCCT\/SCMR\/SIR 2008","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-2167(00)90066-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90644-0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90588-X"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.62.1.26"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2002.31907"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-37-5-867"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520010065026"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(99)70105-7"},{"key":"e_1_2_6_21_2","first-page":"128","article-title":"Pathologic aspects of certain cardiomyopathies","volume":"35","author":"Roberts WC","year":"1974","journal-title":"Circ Res"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00297-4"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00419-5"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.03.023"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-1-6"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.02.010"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.02.010"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.06.085"},{"key":"e_1_2_6_29_2","first-page":"293","article-title":"Relationship of left atrial appendage function to left ventricular function","volume":"56","author":"Mahilmaran A","year":"2004","journal-title":"Indian Heart J"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.2143\/AC.57.2.2005380"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101776"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90022-2"},{"key":"e_1_2_6_33_2","first-page":"3135","article-title":"Predictors of left atrium and left appendage thrombosis in patients with nonvalvular atrial fibrillation","volume":"89","author":"Lu MJ","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.7.451"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000170636.08554.49"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000241064.46659.69"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcu.21953","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.21953","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:28:07Z","timestamp":1700652487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.21953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,22]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1002\/jcu.21953"],"URL":"https:\/\/doi.org\/10.1002\/jcu.21953","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,22]]}}}