{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:09Z","timestamp":1790713389913,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T00:00:00Z","timestamp":1342224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose.<\/jats:title><jats:p>To determine whether gestational sac volume (GSV) or amniotic sac volume (ASV) and\/or the difference between them can predict abortion in women with first\u2010trimester threatened abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Ninety patients between 6 and 12 weeks of gestation presenting with vaginal bleeding were studied. Seventy\u2010six delivered after 24 weeks of gestation (group A) and 14 aborted before 20 weeks of gestation (group B). All patients had a singleton viable pregnancy demonstrated by transvaginal ultrasound. Gestational sac and amniotic sac volumes were measured in all the patients using three\u2010dimensional transvaginal ultrasound with Virtual Organ Computer\u2010aided Analysis software, and the gestational sac volume \u2212 amniotic sac volume (GSV \u2212 ASV) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The groups did not differ in terms of age, parity, number of previous abortions, or term deliveries. The GSV (group A: mean 32.0 \u00b1 27.7 cm<jats:sup>3<\/jats:sup>; group B: 26.7 \u00b1 29.1 cm<jats:sup>3<\/jats:sup>) and the ASV (group A: 21.1 \u00b1 25.5 cm<jats:sup>3<\/jats:sup>; group B: 20.6 \u00b1 26.0 cm<jats:sup>3<\/jats:sup>) were not statistically different, while the GSV \u2212 ASV was significantly smaller in group B (aborting before week 20) (group A: 10.9 \u00b1 10.9 cm<jats:sup>3<\/jats:sup>; group B: 6.1 \u00b1 8.6 cm<jats:sup>3<\/jats:sup>; <jats:italic>p<\/jats:italic> &lt; 0.05). Using receiver operator curves, the area under the curve for predicting normal pregnancy outcome of the GSV \u2212 ASV measurement was 0.654. When the GSV \u2212 ASV was 1.8 cm<jats:sup>3<\/jats:sup> or less, abortion was predicted with 84% sensitivity and 43% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>The measurement of the GSV and the ASV are not good predictors of abortion in patients with first\u2010trimester vaginal bleeding, whereas the use of the GSV \u2212 ASV may be helpful in predicting the outcome of pregnancy. \u00a9 2012 Wiley Periodicals, Inc. 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