{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:06:22Z","timestamp":1759579582654},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T00:00:00Z","timestamp":1343606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To investigate the value of assessing the hepatic parenchymal perfusion in contrast\u2010enhanced ultrasound (CEUS) for evaluating liver fibrosis, using an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Seventy Sprague\u2013Dawley rats were divided into experimental (n = 35) and control (n = 35) groups. In the experimental group, liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride. CEUS of the liver was performed at a 2\u2010week interval for 14 weeks. Signal intensity of liver parenchyma was analyzed with time\u2010intensity curves. Histologic examination of liver specimens of the animals was performed to assess the fibrosis stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The peak signal intensity of hepatic parenchymal perfusion in stage 2\u20133 fibrosis was significantly lower than that in stage 0\u20131. The time to peak intensity of hepatic parenchymal perfusion was significantly longer in the experimental group than the control group, and in the stage 3 fibrosis than in stages 0\u20132 fibrosis. Using time to peak intensity of hepatic parenchymal perfusion to distinguish stage 3 fibrosis and stages 0\u20132 fibrosis, the optimum cutoff was 75,000 milliseconds with the sensitivity and specificity of 67% and 78%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>This animal study showed that CEUS has the potential to be a complementary imaging tool in the evaluation of liver fibrosis. \u00a9 2012 Wiley Periodicals, Inc. J Clin Ultrasound 40:462\u2013470, 2012<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.21969","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T11:10:16Z","timestamp":1343646616000},"page":"462-470","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast\u2010enhanced ultrasound: An animal study"],"prefix":"10.1002","volume":"40","author":[{"given":"Michael","family":"Ying","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Y.H.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L.","family":"Tipoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther S.T.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Queeny W.H.","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Ping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2006.08.005"},{"key":"e_1_2_6_3_2","first-page":"199","article-title":"Portal blood velocity and portal blood flow in patients with chronic viral hepatitis: relation to histological liver fibrosis","volume":"43","author":"Koda M","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180626"},{"key":"e_1_2_6_5_2","first-page":"1029","article-title":"Diagnostic evaluation of carbon tetrachloride\u2010induced rat hepatic cirrhosis model","volume":"25","author":"Lee GP","year":"2005","journal-title":"Anticancer Res"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(03)00212-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(03)00003-5"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2008.01930.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2009.05.010"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-858103"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80141-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2004.tb03238.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01025.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1188"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1313-x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02315.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2011.09.010"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2010.10.012"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2241011352"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.08.016"},{"key":"e_1_2_6_21_2","first-page":"11","article-title":"Detection of early zone 3 liver fibrosis in chronic alcoholics. A comparison of four connective tissue staining methods","volume":"95","author":"Vyberg M","year":"1987","journal-title":"Acta Pathol Microbiol Immunol Scand A"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"key":"e_1_2_6_23_2","first-page":"611","volume-title":"Practical Statistics for Medical Research","author":"Altman DG","year":"1991"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(03)00019-4"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.006"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17551"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcu.21969","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.21969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:16:07Z","timestamp":1696896967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.21969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,30]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/jcu.21969"],"URL":"https:\/\/doi.org\/10.1002\/jcu.21969","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,30]]}}}